Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease

Neeraj Dhaun, Charles J Ferro, Anthony P Davenport, William G Haynes, Jane Goddard, David J Webb

Research output: Contribution to journalArticlepeer-review

Abstract

Endothelin-1 (ET-1) has been implicated in the pathophysiology of chronic kidney disease (CKD) and ET receptor blockade has shown renoprotective effects in animals. We examined the haemodynamic and renal effects of an ET receptor antagonist, TAK-044, in patients with CKD.
Original languageEnglish
Pages (from-to)3228-34
Number of pages7
JournalNephrology dialysis transplantation
Volume22
Issue number11
DOIs
Publication statusPublished - 7 Jun 2007

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