Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease

Neeraj Dhaun; Charles J Ferro; Anthony P Davenport; William G Haynes; Jane Goddard; David J Webb

doi:10.1093/ndt/gfm364

Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease

Neeraj Dhaun
, Charles J Ferro
, Anthony P Davenport
, William G Haynes
, Jane Goddard
, David J Webb

Research output: Contribution to journal › Article › peer-review

Abstract

Endothelin-1 (ET-1) has been implicated in the pathophysiology of chronic kidney disease (CKD) and ET receptor blockade has shown renoprotective effects in animals. We examined the haemodynamic and renal effects of an ET receptor antagonist, TAK-044, in patients with CKD.

Original language	English
Pages (from-to)	3228-34
Number of pages	7
Journal	Nephrology dialysis transplantation
Volume	22
Issue number	11
DOIs	https://doi.org/10.1093/ndt/gfm364
Publication status	Published - 7 Jun 2007

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title = "Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease",

abstract = "Endothelin-1 (ET-1) has been implicated in the pathophysiology of chronic kidney disease (CKD) and ET receptor blockade has shown renoprotective effects in animals. We examined the haemodynamic and renal effects of an ET receptor antagonist, TAK-044, in patients with CKD.",

author = "Neeraj Dhaun and Ferro, \{Charles J\} and Davenport, \{Anthony P\} and Haynes, \{William G\} and Jane Goddard and Webb, \{David J\}",

year = "2007",

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doi = "10.1093/ndt/gfm364",

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AU - Dhaun, Neeraj

AU - Ferro, Charles J

AU - Davenport, Anthony P

AU - Haynes, William G

AU - Goddard, Jane

AU - Webb, David J

PY - 2007/6/7

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N2 - Endothelin-1 (ET-1) has been implicated in the pathophysiology of chronic kidney disease (CKD) and ET receptor blockade has shown renoprotective effects in animals. We examined the haemodynamic and renal effects of an ET receptor antagonist, TAK-044, in patients with CKD.

AB - Endothelin-1 (ET-1) has been implicated in the pathophysiology of chronic kidney disease (CKD) and ET receptor blockade has shown renoprotective effects in animals. We examined the haemodynamic and renal effects of an ET receptor antagonist, TAK-044, in patients with CKD.

U2 - 10.1093/ndt/gfm364

DO - 10.1093/ndt/gfm364

M3 - Article

C2 - 17556408

SN - 0931-0509

VL - 22

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EP - 3234

JO - Nephrology dialysis transplantation

JF - Nephrology dialysis transplantation

IS - 11

ER -

Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease

Abstract

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