Haplotype divergence supports long-term asexuality in the oribatid mite Oppiella nova

Alexander Brandt*, Patrick Tran Van, Christian Bluhm, Yoann Anselmetti, Zoé Dumas, Emeric Figuet, Clémentine M. François, Nicolas Galtier, Bastian Heimburger, Kamil S. Jaron, Marjorie Labédan, Mark Maraun, Darren J. Parker, Marc Robinson-Rechavi, Ina Schaefer, Paul Simion, Stefan Scheu, Tanja Schwander, Jens Bast

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Sex strongly impacts genome evolution via recombination and segregation. In the absence of these processes, haplotypes within lineages of diploid organisms are predicted to accumulate mutations independently of each other and diverge over time. This so-called “Meselson effect” is regarded as a strong indicator of the long-term evolution under obligate asexuality. Here, we present genomic and transcriptomic data of three populations of the asexual oribatid mite species Oppiella nova and its sexual relative Oppiella subpectinata. We document strikingly different patterns of haplotype divergence between the two species, strongly supporting Meselson effect–like evolution and long-term asexuality in O. nova: I) variation within individuals exceeds variation between populations in O. nova but vice versa in O. subpectinata; II) two O. nova sublineages feature a high proportion of lineage-specific heterozygous single-nucleotide polymorphisms (SNPs), indicating that haplotypes continued to diverge after lineage separation; III) the deepest split in gene trees generally separates the two haplotypes in O. nova, but populations in O. subpectinata; and IV) the topologies of the two haplotype trees match each other. Our findings provide positive evidence for the absence of canonical sex over evolutionary time in O. nova and suggest that asexual oribatid mites can escape the dead-end fate usually associated with asexual lineages.

Original languageEnglish
Article numbere2101485118
Number of pages10
JournalProceedings of the National Academy of Sciences (PNAS)
Volume118
Issue number38
DOIs
Publication statusPublished - 21 Sept 2021

Keywords / Materials (for Non-textual outputs)

  • asexuality
  • haplotype divergence
  • meselson effect
  • oribatid mites

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