Haplotypes defined by promoter and intron 1 polymorphisms of the COLIA1 gene regulate bone mineral density in women

Tracy L Stewart, Huilin Jin, Fiona E A McGuigan, Omar M E Albagha, Natalia Garcia-Giralt, Amelia Bassiti, Daniel Grinberg, Susana Balcells, David M Reid, Stuart H Ralston

Research output: Contribution to journalArticlepeer-review

Abstract

The COLIA1 gene is a strong candidate for susceptibility to osteoporosis. The causal genetic variants are currently unclear, but the most likely are functional polymorphisms in the promoter and intron 1 of COLIA1.
Original languageEnglish
Pages (from-to)3575-83
Number of pages9
JournalJournal of Clinical Endocrinology & Metabolism
Volume91
Issue number9
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Absorptiometry, Photon
  • Bone Density
  • Collagen Type I
  • DNA
  • Female
  • Genotype
  • Great Britain
  • Haplotypes
  • Humans
  • Introns
  • Linkage Disequilibrium
  • Middle Aged
  • Osteoporosis
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Promoter Regions, Genetic
  • Sequence Analysis, DNA

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