Harnessing Applied Potential: Selective β-Hydrocarboxylation of Substituted Olefins

Anas Alkayal, Volodymyr Tabas, Stephanie Montanaro, Iain A. Wright, Andrei V. Malkov*, Benjamin R. Buckley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, β-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from β,β-trisubstituted alkenes, in a highly regioselective manner.

Original languageEnglish
JournalJournal of the American Chemical Society
Early online date21 Jan 2020
Publication statusE-pub ahead of print - 21 Jan 2020


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