Hay fever in adolescents and adults

Aziz Sheikh, Sukhmeet S. Panesar, S. Salvilla

Research output: Contribution to journalReview articlepeer-review

Abstract

INTRODUCTION: Hay fever is found throughout the world. Epidemiological evidence suggests considerable geographical variation in its
prevalence. Symptoms are caused by an IgE-mediated type 1 hypersensitivity reaction to airborne allergens such as pollen or fungal spores,
and may also cause eye, sinus, respiratory, and systemic problems. METHODS AND OUTCOMES: We conducted a systematic review
and aimed to answer the following clinical question:What are the effects of treatments for hay fever in adolescents and adults? We searched:
Medline, Embase, The Cochrane Library, and other important databases up to April 2008 (Clinical Evidence reviews are updated periodically;
please check our website for the most up-to-date version of this review).We included harms alerts from relevant organisations such as the
US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS:We found
211 systematic reviews, RCTs, or observational studies that met our inclusion criteria.We performed a GRADE evaluation of the quality of
evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the
following interventions: intranasal corticosteroids, oral antihistamines, intranasal antihistamines, oral leukotriene receptor antagonists, systemic
corticosteroids, intranasal ipratropium bromide, oral decongestants, and combinations of these treatments.
Original languageEnglish
JournalClinical evidence
Publication statusPublished - 18 Nov 2009

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