HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells

Claire Jacob, Carlos N Christen, Jorge A Pereira, Christian Somandin, Arianna Baggiolini, Pirmin Lötscher, Murat Özçelik, Nicolas Tricaud, Dies Meijer, Teppei Yamaguchi, Patrick Matthias, Ueli Suter

Research output: Contribution to journalArticlepeer-review

Abstract

Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin in mutant sciatic nerves. Expression of Sox10 and Krox20, the main transcriptional regulators of Schwann cell myelination, was greatly reduced. We demonstrate that in Schwann cells, HDAC1 and HDAC2 exert specific primary functions: HDAC2 activates the transcriptional program of myelination in synergy with Sox10, whereas HDAC1 controls Schwann cell survival by regulating the levels of active β-catenin.
Original languageEnglish
Pages (from-to)429-436
JournalNature Neuroscience
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Apr 2011

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