Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome

Andrés Coca-Pelaz*, Robert P. Takes, Kate Hutcheson, Nabil F. Saba, Missak Haigentz, Carol R. Bradford, Remco de Bree, Primož Strojan, Valerie J. Lund, William M. Mendenhall, Iain J. Nixon, Miquel Quer, Alessandra Rinaldo, Alfio Ferlito

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalAdvances in Therapy
Volume35
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • Head and neck cancer
  • Oncology
  • Prognosis
  • Survival
  • Treatment
  • Waiting time

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