Heat-shock protein-70 and regulatory T cell-mediated protection from ischemic injury

Stephen O'Neill, Jeremy Hughes

Research output: Contribution to journalArticlepeer-review

Abstract

Heat preconditioning induces heat-shock protein-70 upregulation and protects from renal ischemia/reperfusion injury. Kim et al. report that heat-shock protein-70 and regulatory T cells play a key role in protective heat preconditioning. This work reinforces the utility of inducing heat-shock protein-70 expression by pharmacological agents as a novel therapy for the prevention and treatment of ischemic kidney injury.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalKidney International
Volume85
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Acute Kidney Injury
  • Animals
  • HSP70 Heat-Shock Proteins
  • Male
  • Reperfusion Injury
  • T-Lymphocytes, Regulatory

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