Heat Shock Triggers Assembly of tRNA Synthetases into an Active Supercomplex

Joshua Riback, Pawel Laskowski, Jamie L Scott, Edward WJ Wallace, Alexandra E Rojek, Michael H Schwartz, Tobin R Sosnick, D Allan Drummond

Research output: Contribution to journalMeeting abstractpeer-review

Abstract / Description of output

Heat shock stimulates cellular production of protein folding chaperones. This response is a reaction to, and likely triggered by, protein misfolding and aggregation. Using a proteome-scale mass spectrometry screen for protein aggregation upon heat shock in vivo, we found that many components of the translational apparatus associate into high-molecular weight species. One such component is the ternary yeast multi-tRNA synthetase complex (glutamyl- and methionyl-tRNA synthetases Gus1 and Mes1 with their aminoacylation cofactor Arc1).
Original languageEnglish
Pages (from-to)221a
Number of pages1
JournalBiophysical Journal
Issue numberIssue 2, Supplement 1
Publication statusPublished - 2015


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