Helicoidal transfer matrix model for inhomogeneous DNA melting

T Michoel, Y Van de Peer

Research output: Contribution to journalArticlepeer-review


An inhomogeneous helicoidal nearest-neighbor model with continuous degrees of freedom is shown to predict the same DNA melting properties as traditional long-range Ising models, for free DNA molecules in solution, as well as superhelically stressed DNA with a fixed linking number constraint. Without loss of accuracy, the continuous degrees of freedom can be discretized using a minimal number of discretization points, yielding an effective transfer matrix model of modest dimension (d=36). The resulting algorithms to compute DNA melting profiles are both simple and efficient.

Original languageEnglish
Article number011908
Pages (from-to)-
Number of pages11
JournalPhysical Review E
Issue number1
Publication statusPublished - Jan 2006


Dive into the research topics of 'Helicoidal transfer matrix model for inhomogeneous DNA melting'. Together they form a unique fingerprint.

Cite this