Hematopoietic stem and progenitor cells are present in healthy gingiva tissue

Siddharth Krishnan, Kelly Wemyss, Ian E. Prise, Flora A. Mcclure, Conor O’Boyle, Hayley M. Bridgeman, Tovah N. Shaw, John R. Grainger, Joanne E. Konkel

Research output: Contribution to journalArticlepeer-review

Abstract

Hematopoietic stem cells reside in the bone marrow, where they generate the effector cells that drive immune responses. However, in response to inflammation, some hematopoietic stem and progenitor cells (HSPCs) are recruited to tissue sites and undergo extramedullary hematopoiesis. Contrasting with this paradigm, here we show residence and differentiation of HSPCs in healthy gingiva, a key oral barrier in the absence of overt inflammation. We initially defined a population of gingiva monocytes that could be locally maintained; we subsequently identified not only monocyte progenitors but also diverse HSPCs within the gingiva that could give rise to multiple myeloid lineages. Gingiva HSPCs possessed similar differentiation potentials, reconstitution capabilities, and heterogeneity to bone marrow HSPCs. However, gingival HSPCs responded differently to inflammatory insults, responding to oral but not systemic inflammation. Combined, we highlight a novel pathway of myeloid cell development at a healthy barrier, defining a gingiva-specific HSPC network that supports generation of a proportion of the innate immune cells that police this barrier.
Original languageEnglish
Article numbere20200737
Number of pages14
JournalJournal of Experimental Medicine
Volume218
Issue number4
Early online date26 Feb 2021
DOIs
Publication statusPublished - 5 Apr 2021

Fingerprint Dive into the research topics of 'Hematopoietic stem and progenitor cells are present in healthy gingiva tissue'. Together they form a unique fingerprint.

Cite this