Heme oxygenase system in hepatic ischemia-reperfusion injury

James A Richards, Stephen J Wigmore, Luke R Devey

Research output: Contribution to journalArticlepeer-review


Hepatic ischemia-reperfusion injury (IRI) limits access to transplantation. Heme oxygenase-1 (HO-1) is a powerful antioxidant enzyme which degrades free heme into biliverdin, free iron and carbon monoxide. HO-1 and its metabolites have the ability to modulate a wide variety of inflammatory disorders including hepatic IRI. Mechanisms of this protective effect include reduction of oxygen free radicals, alteration of macrophage and T cell phenotype. Further work is required to understand the physiological importance of the many actions of HO-1 identified experimentally, and to harness the protective effect of HO-1 for therapeutic potential.
Original languageEnglish
Pages (from-to)6068-78
Number of pages11
JournalWorld Journal of Gastroenterology
Issue number48
Publication statusPublished - 2010


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