HEMOSTATIC ABNORMALITIES AND OUTCOME IN PATIENTS WITH OPERABLE BREAST-CANCER

P MCCULLOCH*, GDO LOWE, JT DOUGLAS, GD MURRAY, WD GEORGE

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The predictive value for cancer recurrence of five measurements of haemostatic activity was studied in 89 patients with operable breast cancer. Neither preoperative nor sequential measurements up to 9 months postoperatively of fibrinopeptide A, fibrin fragment B-BETA-15-42, fibrinogen and serum fibrin(ogen) degradation products nor the fibrin plate lysis assay correlated with early recurrent disease. B-BETA-15-42 values were higher preoperatively in patients with oestrogen receptor positive tumours (P = 0.017). Mean B-BETA-15-42 values rose postoperatively (P = 0.003), largely because of an increase in patients with oestrogen receptor negative tumours.

Original languageEnglish
Pages (from-to)950-953
Number of pages4
JournalEuropean Journal of Cancer
Volume26
Issue number9
Publication statusPublished - 1990

Keywords

  • FIBRINOPEPTIDE-A
  • MALIGNANT-TISSUE
  • TUMOR
  • BLOOD
  • ANTICOAGULATION
  • COAGULATION
  • METASTASIS
  • CARCINOMA

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