Hepatic progenitors in liver regeneration

Alexander Raven; Stuart J Forbes

doi:10.1016/j.jhep.2018.03.004

Hepatic progenitors in liver regeneration

Alexander Raven, Stuart J Forbes

Centre for Regenerative Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Hepatocytes can implement a proficient regenerative response after liver injury. However, this regenerative ability diminishes in chronic liver disease where the number of senescent hepatocytes increases.1 This is accompanied by the development of ductular reactions (DR).2 Within the DR are cells that express both biliary epithelial cell (BEC) and hepatocyte features,3 such as shared morphology and keratin expression. It was thought that these cells could be bipotential hepatic progenitor cells (HPCs) that can regenerate both hepatocytes and cholangiocytes.

Original language	English
Journal	Journal of Hepatology
Early online date	31 Oct 2018
DOIs	https://doi.org/10.1016/j.jhep.2018.03.004
Publication status	E-pub ahead of print - 31 Oct 2018

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10.1016/j.jhep.2018.03.004

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title = "Hepatic progenitors in liver regeneration",

abstract = "Hepatocytes can implement a proficient regenerative response after liver injury. However, this regenerative ability diminishes in chronic liver disease where the number of senescent hepatocytes increases.1 This is accompanied by the development of ductular reactions (DR).2 Within the DR are cells that express both biliary epithelial cell (BEC) and hepatocyte features,3 such as shared morphology and keratin expression. It was thought that these cells could be bipotential hepatic progenitor cells (HPCs) that can regenerate both hepatocytes and cholangiocytes.",

author = "Alexander Raven and Forbes, {Stuart J}",

year = "2018",

month = oct,

day = "31",

doi = "10.1016/j.jhep.2018.03.004",

language = "English",

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T1 - Hepatic progenitors in liver regeneration

AU - Raven, Alexander

AU - Forbes, Stuart J

PY - 2018/10/31

Y1 - 2018/10/31

N2 - Hepatocytes can implement a proficient regenerative response after liver injury. However, this regenerative ability diminishes in chronic liver disease where the number of senescent hepatocytes increases.1 This is accompanied by the development of ductular reactions (DR).2 Within the DR are cells that express both biliary epithelial cell (BEC) and hepatocyte features,3 such as shared morphology and keratin expression. It was thought that these cells could be bipotential hepatic progenitor cells (HPCs) that can regenerate both hepatocytes and cholangiocytes.

AB - Hepatocytes can implement a proficient regenerative response after liver injury. However, this regenerative ability diminishes in chronic liver disease where the number of senescent hepatocytes increases.1 This is accompanied by the development of ductular reactions (DR).2 Within the DR are cells that express both biliary epithelial cell (BEC) and hepatocyte features,3 such as shared morphology and keratin expression. It was thought that these cells could be bipotential hepatic progenitor cells (HPCs) that can regenerate both hepatocytes and cholangiocytes.

U2 - 10.1016/j.jhep.2018.03.004

DO - 10.1016/j.jhep.2018.03.004

M3 - Article

C2 - 30391027

SN - 0168-8278

JO - Journal of Hepatology

JF - Journal of Hepatology

ER -

Hepatic progenitors in liver regeneration

Abstract

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