Hepatic progenitors in liver regeneration

Alexander Raven, Stuart J Forbes

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Hepatocytes can implement a proficient regenerative response after liver injury. However, this regenerative ability diminishes in chronic liver disease where the number of senescent hepatocytes increases.1 This is accompanied by the development of ductular reactions (DR).2 Within the DR are cells that express both biliary epithelial cell (BEC) and hepatocyte features,3 such as shared morphology and keratin expression. It was thought that these cells could be bipotential hepatic progenitor cells (HPCs) that can regenerate both hepatocytes and cholangiocytes.
Original languageEnglish
JournalJournal of Hepatology
Early online date31 Oct 2018
DOIs
Publication statusE-pub ahead of print - 31 Oct 2018

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