Hepatitis C virus genotypes: an investigation of type-specific differences in geographic origin and disease

G Dusheiko, H Schmilovitz-Weiss, D Brown, F McOmish, P L Yap, S Sherlock, N McIntyre, P Simmonds

Research output: Contribution to journalArticlepeer-review

Abstract

Because of the nucleotide sequence diversity of different isolates of hepatitis C virus, it has become important to clarify whether distinct genotypes of hepatitis C virus vary with respect to pathogenicity, infectivity, response to antiviral therapy and geographic clustering. We assessed nucleotide sequence variability in the 5' noncoding region of hepatitis C virus, using restriction enzymes to analyze the distribution of hepatitis C virus genotypes, in 80 patients with chronic hepatitis C virus infection. Genotypes were correlated with demographic, clinical and histological features. Thirty-seven patients were infected with type 1, 10 had type 2 and 8 had type 3, and another 23 were infected with a new distinct hepatitis C virus type now classified as type 4. Two were infected with variants whose classification are uncertain. Types 1, 2 and 3 were found in patients from the United Kingdom, southern Europe, Asia, Africa and South America. Nineteen of 23 type 4 genotype isolates were from Middle Eastern patients, compared with 0 of 37 type 1 isolates (p <0.001). Of 21 Middle Eastern patients, 19 (90.4%) had type 4 hepatitis C virus (p = 0.001, odds ratio = 9). We found no significant difference between the mean ages or mean serum aminotransferase concentrations between the various types. Types 1, 2, 3 and 4 were found in patients with mild-to-moderate disease or severe disease. However, 21 of 29 (72.4%) patients with type 1 who underwent liver biopsy had severe chronic hepatitis, cirrhosis or hepatocellular carcinoma histologically; 8 had mild or moderate chronic hepatitis without cirrhosis (p = 0.03, odds ratio = 2.6).(ABSTRACT TRUNCATED AT 250 WORDS)
Original languageEnglish
Pages (from-to)13-8
Number of pages6
JournalHepatology
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 1994

Keywords

  • Adult
  • Chronic Disease
  • Cluster Analysis
  • Egypt
  • Europe
  • Female
  • Genotype
  • Hepacivirus
  • Hepatitis C
  • Humans
  • Interferon-alpha
  • Male
  • Middle Aged
  • Middle East

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