Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor-dependent manner

Christopher J Mee; Michelle J Farquhar; Helen J Harris; Ke Hu; Wenda Ramma; Asif Ahmed; Patrick Maurel; Roy Bicknell; Peter Balfe; Jane A McKeating

doi:10.1053/j.gastro.2009.11.047

Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor-dependent manner

Christopher J Mee, Michelle J Farquhar, Helen J Harris, Ke Hu, Wenda Ramma, Asif Ahmed, Patrick Maurel, Roy Bicknell, Peter Balfe, Jane A McKeating

School of Regeneration and Repair

Research output: Contribution to journal › Article › peer-review

Abstract

Hepatitis C virus (HCV) infection leads to progressive liver disease, frequently culminating in fibrosis and hepatocellular carcinoma. The mechanisms underlying liver injury in chronic hepatitis C are poorly understood. This study evaluated the role of vascular endothelial growth factor (VEGF) in hepatocyte polarity and HCV infection.

Original language	English
Pages (from-to)	1134-42
Number of pages	9
Journal	Gastroenterology
Volume	138
Issue number	3
DOIs	https://doi.org/10.1053/j.gastro.2009.11.047
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

VEGF
Ttopism
HCC
Angiogenesis

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10.1053/j.gastro.2009.11.047

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title = "Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor-dependent manner",

abstract = "Hepatitis C virus (HCV) infection leads to progressive liver disease, frequently culminating in fibrosis and hepatocellular carcinoma. The mechanisms underlying liver injury in chronic hepatitis C are poorly understood. This study evaluated the role of vascular endothelial growth factor (VEGF) in hepatocyte polarity and HCV infection.",

keywords = "VEGF, Ttopism, HCC, Angiogenesis",

author = "Mee, \{Christopher J\} and Farquhar, \{Michelle J\} and Harris, \{Helen J\} and Ke Hu and Wenda Ramma and Asif Ahmed and Patrick Maurel and Roy Bicknell and Peter Balfe and McKeating, \{Jane A\}",

year = "2010",

doi = "10.1053/j.gastro.2009.11.047",

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journal = "Gastroenterology",

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AU - Mee, Christopher J

AU - Farquhar, Michelle J

AU - Harris, Helen J

AU - Hu, Ke

AU - Ramma, Wenda

AU - Ahmed, Asif

AU - Maurel, Patrick

AU - Bicknell, Roy

AU - Balfe, Peter

AU - McKeating, Jane A

PY - 2010

Y1 - 2010

N2 - Hepatitis C virus (HCV) infection leads to progressive liver disease, frequently culminating in fibrosis and hepatocellular carcinoma. The mechanisms underlying liver injury in chronic hepatitis C are poorly understood. This study evaluated the role of vascular endothelial growth factor (VEGF) in hepatocyte polarity and HCV infection.

AB - Hepatitis C virus (HCV) infection leads to progressive liver disease, frequently culminating in fibrosis and hepatocellular carcinoma. The mechanisms underlying liver injury in chronic hepatitis C are poorly understood. This study evaluated the role of vascular endothelial growth factor (VEGF) in hepatocyte polarity and HCV infection.

KW - VEGF

KW - Ttopism

KW - HCC

KW - Angiogenesis

U2 - 10.1053/j.gastro.2009.11.047

DO - 10.1053/j.gastro.2009.11.047

M3 - Article

C2 - 19944696

SN - 0016-5085

VL - 138

SP - 1134

EP - 1142

JO - Gastroenterology

JF - Gastroenterology

IS - 3

ER -

Hepatitis C virus infection reduces hepatocellular polarity in a vascular endothelial growth factor-dependent manner

Abstract

Keywords / Materials (for Non-textual outputs)

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