Hepatitis C virus transmission by intravenous immunoglobulin

P L Yap, F McOmish, A D Webster, L Hammarstrom, C I Smith, J Bjorkander, H D Ochs, S H Fischer, I Quinti, P Simmonds

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The polymerase chain reaction was used to detect hepatitis C virus infection in patients who had previously been reported to have developed non-A, non-B hepatitis after intravenous immunoglobulin infusion. Of the 33 patients with intravenous immunoglobulin associated non-A, non-B hepatitis studied, HCV RNA could be detected in 15 out of 17 patients (88%) who were HCV RNA negative prior to the development of non-A, non-B hepatitis after implicated intravenous immunoglobulin batches. Similarly, eight out of nine patients (89%) in whom no sample was available for polymerase chain reaction testing prior to intravenous immunoglobulin therapy, had detectable HCV RNA after intravenous immunoglobulin therapy with intravenous immunoglobulin batches implicated in non-A, non-B hepatitis transmission. Two of the three intravenous immunoglobulin preparations implicated in non-A, non-B hepatitis transmissions that were available for polymerase chain reaction testing also had detectable HCV RNA, confirming that hepatitis C virus is the implicated virus in intravenous immunoglobulin-associated non-A, non-B hepatitis.
Original languageEnglish
Pages (from-to)455-60
Number of pages6
JournalJournal of Hepatology
Issue number3
Publication statusPublished - Sept 1994

Keywords / Materials (for Non-textual outputs)

  • Hepacivirus
  • Hepatitis C
  • Humans
  • Immunoglobulins, Intravenous
  • Immunologic Deficiency Syndromes
  • Incidence
  • Polymerase Chain Reaction
  • RNA, Viral
  • Retrospective Studies


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