Hepatosteatosis and atherosclerotic plaque on coronary computed tomography angiography

Jessica  Carter; Thomas D   Heseltine; Mohammed N Meah; Evangelos Tzolos; Jacek Kwiecinski; Mhairi Doris; Priscilla  McElhinney; Alastair J  Moss; Philip D Adamson; Amanda L Hunter; Shirjel Alam; Anoop S V Shah; Tania Pawade; Chengjia Wang; Jonathan R  Weir-McCall; Giles Roditi; Edwin J R  van Beek; Edward D Nicol; Leslee J Shaw; Daniel S. Berman; Piotr J Slomka; Nicholas L Mills; Marc R Dweck; David E Newby; Scott W  Murray; Damini Dey; Michelle C Williams

doi:10.1148/ryct.210260

Hepatosteatosis and atherosclerotic plaque on coronary computed tomography angiography

Jessica Carter , Thomas D Heseltine, Mohammed N Meah, Evangelos Tzolos, Jacek Kwiecinski, Mhairi Doris, Priscilla McElhinney , Alastair J Moss, Philip D Adamson, Amanda L Hunter, Shirjel Alam, Anoop S V Shah, Tania Pawade, Chengjia Wang, Jonathan R Weir-McCall , Giles Roditi, Edwin J R van Beek, Edward D Nicol, Leslee J Shaw, Daniel S. BermanPiotr J Slomka, Nicholas L Mills, Marc R Dweck, David E Newby, Scott W Murray , Damini Dey, Michelle C Williams

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose
To assess the association between non-alcoholic fatty liver disease (NAFLD) and quantitative atherosclerotic plaque on CT.

Materials and Methods
In this post-hoc analysis of the prospective Scottish Computed Tomography of the HEART trial (November 2010 to September 2014), hepatosteatosis and coronary artery calcium score were measured on non-contrast CT. Presence of stenoses, visually assessed high-risk plaque, and quantitative plaque burden were assessed on coronary CT angiography. Multivariable models were constructed to assess the impact of hepatosteatosis and cardiovascular risk factors on coronary artery disease.

Results
Images from 1726 participants (mean age, 58 years  9 [standard deviation]; 974 men) were included. Participants with hepatosteatosis (n=155/1726, 9%) had a higher BMI, more hypertension and diabetes mellitus, and higher cardiovascular risk scores (P < .001 for all) compared with those without hepatosteatosis. They had increased coronary artery calcium scores (median, 43 [interquartile range, 0 to 273] Agatston units [AU] versus 19 [0 to 225] AU, P = .046), more non-obstructive disease (48% versus 37%, P = .02) and higher low-attenuation plaque burden (5.11% [0 to 7.16] versus 4.07% [0 to 6.84], P = .04). However, these associations were not independent of cardiovascular risk factors. Over median 4.7 years, there was no evidence of a difference in myocardial infarction between those with and without hepatosteatosis (1.9% versus 2.4%, P = .92).

Conclusion
Hepatosteatosis on CT was associated with an increased prevalence of coronary artery disease on CT, but this was not independent of the presence of cardiovascular risk factors.

Original language	English
Journal	Radiology: Cardiothoracic Imaging
DOIs	https://doi.org/10.1148/ryct.210260
Publication status	Published - 28 Apr 2022

Access to Document

10.1148/ryct.210260

2020 SCOTHEART NAFLD liver PUREAccepted author manuscript, 992 KBLicence: Creative Commons: Attribution (CC-BY)

1 Active
5 Finished

High-Sensitivity Cardiac Troponin Beyond the Acute Coronary Syndrome
Mills, N. (Principal Investigator), Anand, A. (Co-investigator), Chapman, A. (Co-investigator), Ferry, A. (Co-investigator), Newby, D. (Co-investigator), Strachan, F. (Co-investigator) & Tsanas, T. (Co-investigator)
UK-based charities
1/06/20 → 31/05/25
Project: Research
Combined magnetic resonance coronary angiography and positron emission tomography in patients with coronary artery disease
Williams, M. (Principal Investigator)
UK central government bodies/local authorities, health and hospital authorities
1/08/18 → 31/07/19
Project: Research
Non-invasive Imaging of Human Coronary Atherothrombosis
Newby, D. (Principal Investigator)
UK-based charities
1/10/16 → 31/03/22
Project: Research

Edinburgh Imaging Facility
Grant, A. (Manager), van Beek, E. (Manager) & Semple, S. (Manager)
Deanery of Clinical Sciences
Facility/equipment: Facility

Cite this

Carter , J., Heseltine, T. D., Meah, M. N., Tzolos, E., Kwiecinski, J., Doris, M., McElhinney , P., Moss, A. J., Adamson, P. D., Hunter, A. L., Alam, S., Shah, A. S. V., Pawade, T., Wang, C., Weir-McCall , J. R., Roditi, G., van Beek, E. J. R., Nicol, E. D., Shaw, L. J., ... Williams, M. C. (2022). Hepatosteatosis and atherosclerotic plaque on coronary computed tomography angiography. Radiology: Cardiothoracic Imaging. https://doi.org/10.1148/ryct.210260

@article{ed3849c413cb4d72a88929fc4ebefd47,

title = "Hepatosteatosis and atherosclerotic plaque on coronary computed tomography angiography",

abstract = "PurposeTo assess the association between non-alcoholic fatty liver disease (NAFLD) and quantitative atherosclerotic plaque on CT. Materials and MethodsIn this post-hoc analysis of the prospective Scottish Computed Tomography of the HEART trial (November 2010 to September 2014), hepatosteatosis and coronary artery calcium score were measured on non-contrast CT. Presence of stenoses, visually assessed high-risk plaque, and quantitative plaque burden were assessed on coronary CT angiography. Multivariable models were constructed to assess the impact of hepatosteatosis and cardiovascular risk factors on coronary artery disease.ResultsImages from 1726 participants (mean age, 58 years  9 [standard deviation]; 974 men) were included. Participants with hepatosteatosis (n=155/1726, 9%) had a higher BMI, more hypertension and diabetes mellitus, and higher cardiovascular risk scores (P < .001 for all) compared with those without hepatosteatosis. They had increased coronary artery calcium scores (median, 43 [interquartile range, 0 to 273] Agatston units [AU] versus 19 [0 to 225] AU, P = .046), more non-obstructive disease (48% versus 37%, P = .02) and higher low-attenuation plaque burden (5.11% [0 to 7.16] versus 4.07% [0 to 6.84], P = .04). However, these associations were not independent of cardiovascular risk factors. Over median 4.7 years, there was no evidence of a difference in myocardial infarction between those with and without hepatosteatosis (1.9% versus 2.4%, P = .92). Conclusion Hepatosteatosis on CT was associated with an increased prevalence of coronary artery disease on CT, but this was not independent of the presence of cardiovascular risk factors. ",

author = "Jessica Carter and Heseltine, {Thomas D} and Meah, {Mohammed N} and Evangelos Tzolos and Jacek Kwiecinski and Mhairi Doris and Priscilla McElhinney and Moss, {Alastair J} and Adamson, {Philip D} and Hunter, {Amanda L} and Shirjel Alam and Shah, {Anoop S V} and Tania Pawade and Chengjia Wang and Weir-McCall, {Jonathan R} and Giles Roditi and {van Beek}, {Edwin J R} and Nicol, {Edward D} and Shaw, {Leslee J} and Berman, {Daniel S.} and Slomka, {Piotr J} and Mills, {Nicholas L} and Dweck, {Marc R} and Newby, {David E} and Murray, {Scott W} and Damini Dey and Williams, {Michelle C}",

year = "2022",

month = apr,

day = "28",

doi = "10.1148/ryct.210260",

language = "English",

journal = "Radiology: Cardiothoracic Imaging",

issn = "2638-6135",

publisher = "Radiological Society of North America Inc.",

}

Carter , J, Heseltine, TD, Meah, MN, Tzolos, E, Kwiecinski, J, Doris, M, McElhinney , P, Moss, AJ, Adamson, PD, Hunter, AL, Alam, S, Shah, ASV, Pawade, T, Wang, C, Weir-McCall , JR, Roditi, G, van Beek, EJR, Nicol, ED, Shaw, LJ, Berman, DS, Slomka, PJ, Mills, NL , Dweck, MR , Newby, DE, Murray , SW, Dey, D & Williams, MC 2022, 'Hepatosteatosis and atherosclerotic plaque on coronary computed tomography angiography', Radiology: Cardiothoracic Imaging. https://doi.org/10.1148/ryct.210260

TY - JOUR

T1 - Hepatosteatosis and atherosclerotic plaque on coronary computed tomography angiography

AU - Carter , Jessica

AU - Heseltine, Thomas D

AU - Meah, Mohammed N

AU - Tzolos, Evangelos

AU - Kwiecinski, Jacek

AU - Doris, Mhairi

AU - McElhinney , Priscilla

AU - Moss, Alastair J

AU - Adamson, Philip D

AU - Hunter, Amanda L

AU - Alam, Shirjel

AU - Shah, Anoop S V

AU - Pawade, Tania

AU - Wang, Chengjia

AU - Weir-McCall , Jonathan R

AU - Roditi, Giles

AU - van Beek, Edwin J R

AU - Nicol, Edward D

AU - Shaw, Leslee J

AU - Berman, Daniel S.

AU - Slomka, Piotr J

AU - Mills, Nicholas L

AU - Dweck, Marc R

AU - Newby, David E

AU - Murray , Scott W

AU - Dey, Damini

AU - Williams, Michelle C

PY - 2022/4/28

Y1 - 2022/4/28

N2 - PurposeTo assess the association between non-alcoholic fatty liver disease (NAFLD) and quantitative atherosclerotic plaque on CT. Materials and MethodsIn this post-hoc analysis of the prospective Scottish Computed Tomography of the HEART trial (November 2010 to September 2014), hepatosteatosis and coronary artery calcium score were measured on non-contrast CT. Presence of stenoses, visually assessed high-risk plaque, and quantitative plaque burden were assessed on coronary CT angiography. Multivariable models were constructed to assess the impact of hepatosteatosis and cardiovascular risk factors on coronary artery disease.ResultsImages from 1726 participants (mean age, 58 years  9 [standard deviation]; 974 men) were included. Participants with hepatosteatosis (n=155/1726, 9%) had a higher BMI, more hypertension and diabetes mellitus, and higher cardiovascular risk scores (P < .001 for all) compared with those without hepatosteatosis. They had increased coronary artery calcium scores (median, 43 [interquartile range, 0 to 273] Agatston units [AU] versus 19 [0 to 225] AU, P = .046), more non-obstructive disease (48% versus 37%, P = .02) and higher low-attenuation plaque burden (5.11% [0 to 7.16] versus 4.07% [0 to 6.84], P = .04). However, these associations were not independent of cardiovascular risk factors. Over median 4.7 years, there was no evidence of a difference in myocardial infarction between those with and without hepatosteatosis (1.9% versus 2.4%, P = .92). Conclusion Hepatosteatosis on CT was associated with an increased prevalence of coronary artery disease on CT, but this was not independent of the presence of cardiovascular risk factors.

AB - PurposeTo assess the association between non-alcoholic fatty liver disease (NAFLD) and quantitative atherosclerotic plaque on CT. Materials and MethodsIn this post-hoc analysis of the prospective Scottish Computed Tomography of the HEART trial (November 2010 to September 2014), hepatosteatosis and coronary artery calcium score were measured on non-contrast CT. Presence of stenoses, visually assessed high-risk plaque, and quantitative plaque burden were assessed on coronary CT angiography. Multivariable models were constructed to assess the impact of hepatosteatosis and cardiovascular risk factors on coronary artery disease.ResultsImages from 1726 participants (mean age, 58 years  9 [standard deviation]; 974 men) were included. Participants with hepatosteatosis (n=155/1726, 9%) had a higher BMI, more hypertension and diabetes mellitus, and higher cardiovascular risk scores (P < .001 for all) compared with those without hepatosteatosis. They had increased coronary artery calcium scores (median, 43 [interquartile range, 0 to 273] Agatston units [AU] versus 19 [0 to 225] AU, P = .046), more non-obstructive disease (48% versus 37%, P = .02) and higher low-attenuation plaque burden (5.11% [0 to 7.16] versus 4.07% [0 to 6.84], P = .04). However, these associations were not independent of cardiovascular risk factors. Over median 4.7 years, there was no evidence of a difference in myocardial infarction between those with and without hepatosteatosis (1.9% versus 2.4%, P = .92). Conclusion Hepatosteatosis on CT was associated with an increased prevalence of coronary artery disease on CT, but this was not independent of the presence of cardiovascular risk factors.

U2 - 10.1148/ryct.210260

DO - 10.1148/ryct.210260

M3 - Article

SN - 2638-6135

JO - Radiology: Cardiothoracic Imaging

JF - Radiology: Cardiothoracic Imaging

ER -

Hepatosteatosis and atherosclerotic plaque on coronary computed tomography angiography

Abstract

Access to Document

Fingerprint

Projects

High-Sensitivity Cardiac Troponin Beyond the Acute Coronary Syndrome

Combined magnetic resonance coronary angiography and positron emission tomography in patients with coronary artery disease

Non-invasive Imaging of Human Coronary Atherothrombosis

Equipment

Edinburgh Imaging Facility

Cite this