Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

Emily Vasiliadou, Vasiliki Karakitsou, George Kazakos, Ioannis Oikonomidis, Theodora Tsouloufi, Panagiotis Kosmas, Osheiza Abdulmalik, Christos Koutinas, Urs Giger, Mathios Mylonakis

Research output: Contribution to journalArticlepeer-review


A one-year-old, female domestic shorthair cat was referred for ovariohysterectomy with a history of cyanotic mucous membranes for several months. Blood samples exhibited a noticeably brownish blood discoloration, while laboratory screening revealed mild-to-moderate erythrocytosis and near normal partial arterial oxygen pressure. Blood methemoglobin content was 41% of total hemoglobin concentration, and erythrocytic methemoglobin reductase activity was <1% compared with control samples. A diagnosis of hereditary methemoglobinemia was established. After an intravenous injection of methylene blue, the cat’s mucous membranes became transiently pink, and the ovariohysterectomy was uneventfully performed. Methylene blue may have improved safety during anesthesia and surgery.
Original languageEnglish
Number of pages502
JournalThe Canadian veterinary journal. La revue vétérinaire canadienne
Publication statusPublished - May 2019


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