Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

Emily Vasiliadou; Vasiliki Karakitsou; George Kazakos; Ioannis Oikonomidis; Theodora Tsouloufi; Panagiotis Kosmas; Osheiza Abdulmalik; Christos  Koutinas; Urs Giger; Mathios Mylonakis

Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

Emily Vasiliadou, Vasiliki Karakitsou, George Kazakos, Ioannis Oikonomidis, Theodora Tsouloufi, Panagiotis Kosmas, Osheiza Abdulmalik, Christos Koutinas, Urs Giger, Mathios Mylonakis

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

A one-year-old, female domestic shorthair cat was referred for ovariohysterectomy with a history of cyanotic mucous membranes for several months. Blood samples exhibited a noticeably brownish blood discoloration, while laboratory screening revealed mild-to-moderate erythrocytosis and near normal partial arterial oxygen pressure. Blood methemoglobin content was 41% of total hemoglobin concentration, and erythrocytic methemoglobin reductase activity was <1% compared with control samples. A diagnosis of hereditary methemoglobinemia was established. After an intravenous injection of methylene blue, the cat’s mucous membranes became transiently pink, and the ovariohysterectomy was uneventfully performed. Methylene blue may have improved safety during anesthesia and surgery.

Original language	English
Number of pages	502
Journal	The Canadian veterinary journal. La revue vétérinaire canadienne
Volume	60
Publication status	Published - May 2019

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https://www.canadianveterinarians.net/pdf/CVJ/cvj_vol60_no5.pdf

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Vasiliadou, E., Karakitsou, V., Kazakos, G., Oikonomidis, I., Tsouloufi, T., Kosmas, P., Abdulmalik, O., Koutinas, C., Giger, U., & Mylonakis, M. (2019). Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy. The Canadian veterinary journal. La revue vétérinaire canadienne, 60. https://www.canadianveterinarians.net/pdf/CVJ/cvj_vol60_no5.pdf

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abstract = "A one-year-old, female domestic shorthair cat was referred for ovariohysterectomy with a history of cyanotic mucous membranes for several months. Blood samples exhibited a noticeably brownish blood discoloration, while laboratory screening revealed mild-to-moderate erythrocytosis and near normal partial arterial oxygen pressure. Blood methemoglobin content was 41% of total hemoglobin concentration, and erythrocytic methemoglobin reductase activity was <1% compared with control samples. A diagnosis of hereditary methemoglobinemia was established. After an intravenous injection of methylene blue, the cat{\textquoteright}s mucous membranes became transiently pink, and the ovariohysterectomy was uneventfully performed. Methylene blue may have improved safety during anesthesia and surgery.",

author = "Emily Vasiliadou and Vasiliki Karakitsou and George Kazakos and Ioannis Oikonomidis and Theodora Tsouloufi and Panagiotis Kosmas and Osheiza Abdulmalik and Christos Koutinas and Urs Giger and Mathios Mylonakis",

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T1 - Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

AU - Vasiliadou, Emily

AU - Karakitsou, Vasiliki

AU - Kazakos, George

AU - Oikonomidis, Ioannis

AU - Tsouloufi, Theodora

AU - Kosmas, Panagiotis

AU - Abdulmalik, Osheiza

AU - Koutinas, Christos

AU - Giger, Urs

AU - Mylonakis, Mathios

PY - 2019/5

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N2 - A one-year-old, female domestic shorthair cat was referred for ovariohysterectomy with a history of cyanotic mucous membranes for several months. Blood samples exhibited a noticeably brownish blood discoloration, while laboratory screening revealed mild-to-moderate erythrocytosis and near normal partial arterial oxygen pressure. Blood methemoglobin content was 41% of total hemoglobin concentration, and erythrocytic methemoglobin reductase activity was <1% compared with control samples. A diagnosis of hereditary methemoglobinemia was established. After an intravenous injection of methylene blue, the cat’s mucous membranes became transiently pink, and the ovariohysterectomy was uneventfully performed. Methylene blue may have improved safety during anesthesia and surgery.

AB - A one-year-old, female domestic shorthair cat was referred for ovariohysterectomy with a history of cyanotic mucous membranes for several months. Blood samples exhibited a noticeably brownish blood discoloration, while laboratory screening revealed mild-to-moderate erythrocytosis and near normal partial arterial oxygen pressure. Blood methemoglobin content was 41% of total hemoglobin concentration, and erythrocytic methemoglobin reductase activity was <1% compared with control samples. A diagnosis of hereditary methemoglobinemia was established. After an intravenous injection of methylene blue, the cat’s mucous membranes became transiently pink, and the ovariohysterectomy was uneventfully performed. Methylene blue may have improved safety during anesthesia and surgery.

M3 - Article

VL - 60

JO - The Canadian veterinary journal. La revue vétérinaire canadienne

JF - The Canadian veterinary journal. La revue vétérinaire canadienne

SN - 0008-5286

ER -

Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

Abstract

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