Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

Emily Vasiliadou; Vasiliki Karakitsou; George Kazakos; Ioannis Oikonomidis; Theodora Tsouloufi; Panagiotis Kosmas; Osheiza Abdulmalik; Christos  Koutinas; Urs Giger; Mathios Mylonakis

Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy

Emily Vasiliadou, Vasiliki Karakitsou, George Kazakos, Ioannis Oikonomidis, Theodora Tsouloufi, Panagiotis Kosmas, Osheiza Abdulmalik, Christos Koutinas, Urs Giger, Mathios Mylonakis

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

A one-year-old, female domestic shorthair cat was referred for ovariohysterectomy with a history of cyanotic mucous membranes for several months. Blood samples exhibited a noticeably brownish blood discoloration, while laboratory screening revealed mild-to-moderate erythrocytosis and near normal partial arterial oxygen pressure. Blood methemoglobin content was 41% of total hemoglobin concentration, and erythrocytic methemoglobin reductase activity was <1% compared with control samples. A diagnosis of hereditary methemoglobinemia was established. After an intravenous injection of methylene blue, the cat’s mucous membranes became transiently pink, and the ovariohysterectomy was uneventfully performed. Methylene blue may have improved safety during anesthesia and surgery.

Original language	English
Number of pages	502
Journal	The Canadian veterinary journal. La revue vétérinaire canadienne
Volume	60
Publication status	Published - May 2019

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Feline Methemoglobinemia CVJ 2018 revision 3Accepted author manuscript, 51.7 KB

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Vasiliadou, E., Karakitsou, V., Kazakos, G., Oikonomidis, I., Tsouloufi, T., Kosmas, P., Abdulmalik, O., Koutinas, C., Giger, U., & Mylonakis, M. (2019). Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy. The Canadian veterinary journal. La revue vétérinaire canadienne, 60. https://www.canadianveterinarians.net/pdf/CVJ/cvj_vol60_no5.pdf

Vasiliadou, Emily ; Karakitsou, Vasiliki ; Kazakos, George ; Oikonomidis, Ioannis ; Tsouloufi, Theodora ; Kosmas, Panagiotis ; Abdulmalik, Osheiza ; Koutinas, Christos ; Giger, Urs ; Mylonakis, Mathios. / Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy. In: The Canadian veterinary journal. La revue vétérinaire canadienne. 2019 ; Vol. 60.

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abstract = "A one-year-old, female domestic shorthair cat was referred for ovariohysterectomy with a history of cyanotic mucous membranes for several months. Blood samples exhibited a noticeably brownish blood discoloration, while laboratory screening revealed mild-to-moderate erythrocytosis and near normal partial arterial oxygen pressure. Blood methemoglobin content was 41% of total hemoglobin concentration, and erythrocytic methemoglobin reductase activity was <1% compared with control samples. A diagnosis of hereditary methemoglobinemia was established. After an intravenous injection of methylene blue, the cat{\textquoteright}s mucous membranes became transiently pink, and the ovariohysterectomy was uneventfully performed. Methylene blue may have improved safety during anesthesia and surgery.",

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Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy. / Vasiliadou, Emily; Karakitsou, Vasiliki; Kazakos, George; Oikonomidis, Ioannis; Tsouloufi, Theodora; Kosmas, Panagiotis; Abdulmalik, Osheiza; Koutinas, Christos ; Giger, Urs; Mylonakis, Mathios.

In: The Canadian veterinary journal. La revue vétérinaire canadienne, Vol. 60, 05.2019.

Research output: Contribution to journal › Article › peer-review

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AU - Karakitsou, Vasiliki

AU - Kazakos, George

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AU - Tsouloufi, Theodora

AU - Kosmas, Panagiotis

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AU - Koutinas, Christos

AU - Giger, Urs

AU - Mylonakis, Mathios

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AB - A one-year-old, female domestic shorthair cat was referred for ovariohysterectomy with a history of cyanotic mucous membranes for several months. Blood samples exhibited a noticeably brownish blood discoloration, while laboratory screening revealed mild-to-moderate erythrocytosis and near normal partial arterial oxygen pressure. Blood methemoglobin content was 41% of total hemoglobin concentration, and erythrocytic methemoglobin reductase activity was <1% compared with control samples. A diagnosis of hereditary methemoglobinemia was established. After an intravenous injection of methylene blue, the cat’s mucous membranes became transiently pink, and the ovariohysterectomy was uneventfully performed. Methylene blue may have improved safety during anesthesia and surgery.

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JO - The Canadian veterinary journal. La revue vétérinaire canadienne

JF - The Canadian veterinary journal. La revue vétérinaire canadienne

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