Heritability in the genomics era - concepts and misconceptions

Peter M. Visscher, William G. Hill, Naomi R. Wray

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Heritability allows a comparison of the relative importance of genes and environment to the variation of traits within and across populations. The concept of heritability and its definition as an estimable, dimensionless population parameter was introduced by Sewall Wright and Ronald Fisher nearly a century ago. Despite continuous misunderstandings and controversies over its use and application, heritability remains key to the response to selection in evolutionary biology and agriculture, and to the prediction of disease risk in medicine. Recent reports of substantial heritability for gene expression and new estimation methods using marker data highlight the relevance of heritability in the genomics era.

Original languageEnglish
Pages (from-to)255-266
Number of pages12
JournalNature Reviews Genetics
Volume9
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Dive into the research topics of 'Heritability in the genomics era - concepts and misconceptions'. Together they form a unique fingerprint.

Cite this