Heritability of syringomyelia in Cavalier King Charles spaniels

Tom Lewis, Clare Rusbridge, Penny Knowler, Sarah Blott, John A. Woolliams

Research output: Contribution to journalArticlepeer-review

Abstract

Mixed model analysis of 384 Cavalier King Charles spaniels (CKCS), with a magnetic resonance imaging diagnosis for the presence or absence of a syrinx, in conjunction with the Kennel Club pedigree records of all dogs registered from the mid 1980s to September 2007, revealed a moderately high estimate of heritability, of syringomyelia (h(2) = 0.37 +/- 0.15 standard error) when analysed as a binary trait. Inspection of cases where the disease segregated within families pointed to genes at more than one locus influencing syringomyelia. The availability of estimated breeding values for Kennel Club registered CKCS is a significant step in being able to select against syringomyelia, particularly given the difficulty of ascertaining the disease phenotype. (C) 2009 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)345-347
Number of pages3
JournalVeterinary Journal
Volume183
Issue number3
DOIs
Publication statusPublished - Mar 2010

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