Heritability of syringomyelia in Cavalier King Charles spaniels

Tom Lewis; Clare Rusbridge; Penny Knowler; Sarah Blott; John A. Woolliams

doi:10.1016/j.tvjl.2009.10.022

Heritability of syringomyelia in Cavalier King Charles spaniels

Tom Lewis, Clare Rusbridge, Penny Knowler, Sarah Blott, John A. Woolliams

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Mixed model analysis of 384 Cavalier King Charles spaniels (CKCS), with a magnetic resonance imaging diagnosis for the presence or absence of a syrinx, in conjunction with the Kennel Club pedigree records of all dogs registered from the mid 1980s to September 2007, revealed a moderately high estimate of heritability, of syringomyelia (h(2) = 0.37 +/- 0.15 standard error) when analysed as a binary trait. Inspection of cases where the disease segregated within families pointed to genes at more than one locus influencing syringomyelia. The availability of estimated breeding values for Kennel Club registered CKCS is a significant step in being able to select against syringomyelia, particularly given the difficulty of ascertaining the disease phenotype. (C) 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	345-347
Number of pages	3
Journal	Veterinary Journal
Volume	183
Issue number	3
DOIs	https://doi.org/10.1016/j.tvjl.2009.10.022
Publication status	Published - Mar 2010

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10.1016/j.tvjl.2009.10.022

http://www.sciencedirect.com/science/article/pii/S1090023309004274

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title = "Heritability of syringomyelia in Cavalier King Charles spaniels",

abstract = "Mixed model analysis of 384 Cavalier King Charles spaniels (CKCS), with a magnetic resonance imaging diagnosis for the presence or absence of a syrinx, in conjunction with the Kennel Club pedigree records of all dogs registered from the mid 1980s to September 2007, revealed a moderately high estimate of heritability, of syringomyelia (h(2) = 0.37 +/- 0.15 standard error) when analysed as a binary trait. Inspection of cases where the disease segregated within families pointed to genes at more than one locus influencing syringomyelia. The availability of estimated breeding values for Kennel Club registered CKCS is a significant step in being able to select against syringomyelia, particularly given the difficulty of ascertaining the disease phenotype. (C) 2009 Elsevier Ltd. All rights reserved.",

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AU - Lewis, Tom

AU - Rusbridge, Clare

AU - Knowler, Penny

AU - Blott, Sarah

AU - Woolliams, John A.

PY - 2010/3

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N2 - Mixed model analysis of 384 Cavalier King Charles spaniels (CKCS), with a magnetic resonance imaging diagnosis for the presence or absence of a syrinx, in conjunction with the Kennel Club pedigree records of all dogs registered from the mid 1980s to September 2007, revealed a moderately high estimate of heritability, of syringomyelia (h(2) = 0.37 +/- 0.15 standard error) when analysed as a binary trait. Inspection of cases where the disease segregated within families pointed to genes at more than one locus influencing syringomyelia. The availability of estimated breeding values for Kennel Club registered CKCS is a significant step in being able to select against syringomyelia, particularly given the difficulty of ascertaining the disease phenotype. (C) 2009 Elsevier Ltd. All rights reserved.

AB - Mixed model analysis of 384 Cavalier King Charles spaniels (CKCS), with a magnetic resonance imaging diagnosis for the presence or absence of a syrinx, in conjunction with the Kennel Club pedigree records of all dogs registered from the mid 1980s to September 2007, revealed a moderately high estimate of heritability, of syringomyelia (h(2) = 0.37 +/- 0.15 standard error) when analysed as a binary trait. Inspection of cases where the disease segregated within families pointed to genes at more than one locus influencing syringomyelia. The availability of estimated breeding values for Kennel Club registered CKCS is a significant step in being able to select against syringomyelia, particularly given the difficulty of ascertaining the disease phenotype. (C) 2009 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.tvjl.2009.10.022

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JO - Veterinary Journal

JF - Veterinary Journal

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ER -

Heritability of syringomyelia in Cavalier King Charles spaniels

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