Herpesviral protein networks and their interaction with the human proteome

P  Uetz; Y A  Dong; C  Zeretzke; C  Atzler; A  Baiker; B  Berger; S V  Rajagopala; M  Roupelieva; E  Fossum; J  Haas

doi:10.1126/science.1116804

Herpesviral protein networks and their interaction with the human proteome

P Uetz, Y A Dong, C Zeretzke, C Atzler, A Baiker, B Berger, S V Rajagopala, M Roupelieva, E Fossum, J Haas

Deanery of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The comprehensive yeast two-hybrid analysis of intraviral protein interactions in two members of the herpesvirus family, Kaposi sarcoma-associated herpesvirus (KSHV) and varicella-zoster virus (VZV), revealed 123 and 173 interactions, respectively. Viral protein interaction networks resemble single, highly coupled modules, whereas cellular networks are organized in separate functional submodules. Predicted and experimentally verified interactions between KSHV and human proteins were used to connect the viral interactome into a prototypical human interactome and to simulate infection. The analysis of the combined system showed that the viral network adopts cellular network features and that protein networks of herpesviruses and possibly other intracellular pathogens have distinguishing topologies.

Original language	English
Pages (from-to)	239-242
Number of pages	4
Journal	Science
Volume	311
Issue number	5758
DOIs	https://doi.org/10.1126/science.1116804
Publication status	Published - 13 Jan 2006

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title = "Herpesviral protein networks and their interaction with the human proteome",

abstract = "The comprehensive yeast two-hybrid analysis of intraviral protein interactions in two members of the herpesvirus family, Kaposi sarcoma-associated herpesvirus (KSHV) and varicella-zoster virus (VZV), revealed 123 and 173 interactions, respectively. Viral protein interaction networks resemble single, highly coupled modules, whereas cellular networks are organized in separate functional submodules. Predicted and experimentally verified interactions between KSHV and human proteins were used to connect the viral interactome into a prototypical human interactome and to simulate infection. The analysis of the combined system showed that the viral network adopts cellular network features and that protein networks of herpesviruses and possibly other intracellular pathogens have distinguishing topologies.",

author = "P Uetz and Dong, {Y A} and C Zeretzke and C Atzler and A Baiker and B Berger and Rajagopala, {S V} and M Roupelieva and E Fossum and J Haas",

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AU - Uetz, P

AU - Dong, Y A

AU - Zeretzke, C

AU - Atzler, C

AU - Baiker, A

AU - Berger, B

AU - Rajagopala, S V

AU - Roupelieva, M

AU - Fossum, E

AU - Haas, J

PY - 2006/1/13

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AB - The comprehensive yeast two-hybrid analysis of intraviral protein interactions in two members of the herpesvirus family, Kaposi sarcoma-associated herpesvirus (KSHV) and varicella-zoster virus (VZV), revealed 123 and 173 interactions, respectively. Viral protein interaction networks resemble single, highly coupled modules, whereas cellular networks are organized in separate functional submodules. Predicted and experimentally verified interactions between KSHV and human proteins were used to connect the viral interactome into a prototypical human interactome and to simulate infection. The analysis of the combined system showed that the viral network adopts cellular network features and that protein networks of herpesviruses and possibly other intracellular pathogens have distinguishing topologies.

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VL - 311

SP - 239

EP - 242

JO - Science

JF - Science

IS - 5758

ER -

Herpesviral protein networks and their interaction with the human proteome

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