Projects per year
Abstract
T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1hi Tfh are important in the GC response, the function of the PD1lo Tfh-like subset is unknown. We show that these cells, like the PD1hi GC-Tfh, depend upon B cells; however, their entry to follicles is independent of CXCR5 or cognate interactions with B cells. The differentiation into PD1hi Tfh is dependent on MHC class II interactions with B cells and requires CXCR5. Our data suggest a Tfh differentiation pathway that is initially B cell-independent, then dependent on non-cognate B cell interactions, and finally following cognate interaction with B cells and CXCR5-ligands allows the formation of GC-Tfh. The PD1lo Tfh-like cells make early cytokine responses and may represent precursors of CD4 memory cells.
Original language | English |
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Article number | 489 |
Journal | Frontiers in Immunology |
Volume | 8 |
Issue number | APR |
DOIs | |
Publication status | Published - 28 Apr 2017 |
Keywords
- Germinal centres
- T cell heterogeneity
- T cell memory
- T follicular helper cell subsets
- T follicular helper cells
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- 1 Finished
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T follicular helper cells, a critical step in the pathway to CD4 T cell memory
1/05/11 → 31/03/15
Project: Research
Profiles
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David Gray
- School of Biological Sciences - Head of School, Professor of Immunology
Person: Academic: Research Active