Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control

L Matthews; J C Low; D L Gally; M C Pearce; D J Mellor; J A P Heesterbeek; M Chase-Topping; S W Naylor; D J Shaw; S W J Reid; G J Gunn; M E J Woolhouse

doi:10.1073/pnas.0503776103

Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control

L Matthews, J C Low, D L Gally, M C Pearce, D J Mellor, J A P Heesterbeek, M Chase-Topping, S W Naylor, D J Shaw, S W J Reid, G J Gunn, M E J Woolhouse

Research output: Contribution to journal › Article › peer-review

Abstract

Identification of the relative importance of within- and between-host variability in infectiousness and the impact of these heterogeneities on the transmission dynamics of infectious agents can enable efficient targeting of control measures. Cattle, a major reservoir host for the zoonotic pathogen Escherichia coli O157, are known to exhibit a high degree of heterogeneity in bacterial shedding densities. By relating bacterial count to infectiousness and fitting dynamic epidemiological models to prevalence data from a cross-sectional survey of cattle farms in Scotland, we identify a robust pattern: approximately 80% of the transmission arises from the 20% most infectious individuals. We examine potential control options under a range of assumptions about within- and between-host variability in infection dynamics. Our results show that the within-herd basic reproduction ratio, R(0), could be reduced to

Original language	English
Pages (from-to)	547-52
Number of pages	6
Journal	Proceedings of the National Academy of Sciences (PNAS)
Volume	103
Issue number	3
DOIs	https://doi.org/10.1073/pnas.0503776103
Publication status	Published - 2006

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10.1073/pnas.0503776103

Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control
Freely available online through the PNAS open access option. Copyright © 2006, The National Academy of Sciences
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http://www.pnas.org/content/103/3/547

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Matthews, L., Low, J. C., Gally, D. L., Pearce, M. C., Mellor, D. J., Heesterbeek, J. A. P., Chase-Topping, M., Naylor, S. W., Shaw, D. J., Reid, S. W. J., Gunn, G. J., & Woolhouse, M. E. J. (2006). Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control. Proceedings of the National Academy of Sciences (PNAS), 103(3), 547-52. https://doi.org/10.1073/pnas.0503776103

@article{c088cef4a1e6405abf288d0370098c63,

title = "Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control",

abstract = "Identification of the relative importance of within- and between-host variability in infectiousness and the impact of these heterogeneities on the transmission dynamics of infectious agents can enable efficient targeting of control measures. Cattle, a major reservoir host for the zoonotic pathogen Escherichia coli O157, are known to exhibit a high degree of heterogeneity in bacterial shedding densities. By relating bacterial count to infectiousness and fitting dynamic epidemiological models to prevalence data from a cross-sectional survey of cattle farms in Scotland, we identify a robust pattern: approximately 80% of the transmission arises from the 20% most infectious individuals. We examine potential control options under a range of assumptions about within- and between-host variability in infection dynamics. Our results show that the within-herd basic reproduction ratio, R(0), could be reduced to ",

author = "L Matthews and Low, {J C} and Gally, {D L} and Pearce, {M C} and Mellor, {D J} and Heesterbeek, {J A P} and M Chase-Topping and Naylor, {S W} and Shaw, {D J} and Reid, {S W J} and Gunn, {G J} and Woolhouse, {M E J}",

year = "2006",

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language = "English",

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Matthews, L, Low, JC, Gally, DL, Pearce, MC, Mellor, DJ, Heesterbeek, JAP, Chase-Topping, M, Naylor, SW, Shaw, DJ, Reid, SWJ, Gunn, GJ & Woolhouse, MEJ 2006, 'Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control', Proceedings of the National Academy of Sciences (PNAS), vol. 103, no. 3, pp. 547-52. https://doi.org/10.1073/pnas.0503776103

TY - JOUR

T1 - Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control

AU - Matthews, L

AU - Low, J C

AU - Gally, D L

AU - Pearce, M C

AU - Mellor, D J

AU - Heesterbeek, J A P

AU - Chase-Topping, M

AU - Naylor, S W

AU - Shaw, D J

AU - Reid, S W J

AU - Gunn, G J

AU - Woolhouse, M E J

PY - 2006

Y1 - 2006

N2 - Identification of the relative importance of within- and between-host variability in infectiousness and the impact of these heterogeneities on the transmission dynamics of infectious agents can enable efficient targeting of control measures. Cattle, a major reservoir host for the zoonotic pathogen Escherichia coli O157, are known to exhibit a high degree of heterogeneity in bacterial shedding densities. By relating bacterial count to infectiousness and fitting dynamic epidemiological models to prevalence data from a cross-sectional survey of cattle farms in Scotland, we identify a robust pattern: approximately 80% of the transmission arises from the 20% most infectious individuals. We examine potential control options under a range of assumptions about within- and between-host variability in infection dynamics. Our results show that the within-herd basic reproduction ratio, R(0), could be reduced to

AB - Identification of the relative importance of within- and between-host variability in infectiousness and the impact of these heterogeneities on the transmission dynamics of infectious agents can enable efficient targeting of control measures. Cattle, a major reservoir host for the zoonotic pathogen Escherichia coli O157, are known to exhibit a high degree of heterogeneity in bacterial shedding densities. By relating bacterial count to infectiousness and fitting dynamic epidemiological models to prevalence data from a cross-sectional survey of cattle farms in Scotland, we identify a robust pattern: approximately 80% of the transmission arises from the 20% most infectious individuals. We examine potential control options under a range of assumptions about within- and between-host variability in infection dynamics. Our results show that the within-herd basic reproduction ratio, R(0), could be reduced to

U2 - 10.1073/pnas.0503776103

DO - 10.1073/pnas.0503776103

M3 - Article

C2 - 16407143

SN - 0027-8424

VL - 103

SP - 547

EP - 552

JO - Proceedings of the National Academy of Sciences (PNAS)

JF - Proceedings of the National Academy of Sciences (PNAS)

IS - 3

ER -

Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control

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