High-Density Polymer Microarrays: Identifying Synthetic Polymers that Control Human Embryonic Stem Cell Growth

Anne Hansen; Heidi K. Mjoseng; Rong Zhang; Michail Kalloudis; Vasileios Koutsos; Paul A. de Sousa; Mark Bradley

doi:10.1002/adhm.201300489

High-Density Polymer Microarrays: Identifying Synthetic Polymers that Control Human Embryonic Stem Cell Growth

Anne Hansen, Heidi K. Mjoseng, Rong Zhang, Michail Kalloudis, Vasileios Koutsos, Paul A. de Sousa, Mark Bradley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The fabrication of high-density polymer microarray is described, allowing the simultaneous and efficient evaluation of more than 7000 different polymers in a single-cellular-based screen. These high-density polymer arrays are applied in the search for synthetic substrates for hESCs culture. Up-scaling of the identified hit polymers enables long-term cellular cultivation and promoted successful stem-cell maintenance.

Original language	English
Pages (from-to)	848-853
Number of pages	6
Journal	Advanced Healthcare Materials
Volume	3
Issue number	6
DOIs	https://doi.org/10.1002/adhm.201300489
Publication status	Published - Jun 2014

Keywords / Materials (for Non-textual outputs)

SELF-RENEWAL
BIOMATERIALS
CULTURE
PLURIPOTENCY
HYDROGELS
THERAPY
DISEASE
LINES

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10.1002/adhm.201300489

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@article{ec1a4b9c5ecf48c598092764d34a3202,

title = "High-Density Polymer Microarrays: Identifying Synthetic Polymers that Control Human Embryonic Stem Cell Growth",

abstract = "The fabrication of high-density polymer microarray is described, allowing the simultaneous and efficient evaluation of more than 7000 different polymers in a single-cellular-based screen. These high-density polymer arrays are applied in the search for synthetic substrates for hESCs culture. Up-scaling of the identified hit polymers enables long-term cellular cultivation and promoted successful stem-cell maintenance.",

keywords = "SELF-RENEWAL, BIOMATERIALS, CULTURE, PLURIPOTENCY, HYDROGELS, THERAPY, DISEASE, LINES",

author = "Anne Hansen and Mjoseng, \{Heidi K.\} and Rong Zhang and Michail Kalloudis and Vasileios Koutsos and \{de Sousa\}, \{Paul A.\} and Mark Bradley",

note = "{\textcopyright} 2013 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2014",

month = jun,

doi = "10.1002/adhm.201300489",

language = "English",

volume = "3",

pages = "848--853",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

publisher = "Wiley",

number = "6",

}

TY - JOUR

T1 - High-Density Polymer Microarrays

T2 - Identifying Synthetic Polymers that Control Human Embryonic Stem Cell Growth

AU - Hansen, Anne

AU - Mjoseng, Heidi K.

AU - Zhang, Rong

AU - Kalloudis, Michail

AU - Koutsos, Vasileios

AU - de Sousa, Paul A.

AU - Bradley, Mark

PY - 2014/6

Y1 - 2014/6

N2 - The fabrication of high-density polymer microarray is described, allowing the simultaneous and efficient evaluation of more than 7000 different polymers in a single-cellular-based screen. These high-density polymer arrays are applied in the search for synthetic substrates for hESCs culture. Up-scaling of the identified hit polymers enables long-term cellular cultivation and promoted successful stem-cell maintenance.

AB - The fabrication of high-density polymer microarray is described, allowing the simultaneous and efficient evaluation of more than 7000 different polymers in a single-cellular-based screen. These high-density polymer arrays are applied in the search for synthetic substrates for hESCs culture. Up-scaling of the identified hit polymers enables long-term cellular cultivation and promoted successful stem-cell maintenance.

KW - SELF-RENEWAL

KW - BIOMATERIALS

KW - CULTURE

KW - PLURIPOTENCY

KW - HYDROGELS

KW - THERAPY

KW - DISEASE

KW - LINES

U2 - 10.1002/adhm.201300489

DO - 10.1002/adhm.201300489

M3 - Article

C2 - 24353271

SN - 2192-2640

VL - 3

SP - 848

EP - 853

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 6

ER -

High-Density Polymer Microarrays: Identifying Synthetic Polymers that Control Human Embryonic Stem Cell Growth

Abstract

Keywords / Materials (for Non-textual outputs)

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