High frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases

Anita Steinbakk; Anais Malpica; Aida Slewa; Einar Gudlaugsson; Emiel A M Janssen; Mark Arends; Arnold Jan Kruse; Yu Yinhua; Weiwei Feng; Jan P Baak

doi:10.1007/s13402-011-0040-x

High frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases

Anita Steinbakk, Anais Malpica, Aida Slewa, Einar Gudlaugsson, Emiel A M Janssen, Mark Arends, Arnold Jan Kruse, Yu Yinhua, Weiwei Feng, Jan P Baak

School of Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

To analyze the prognostic value of microsatellite instability (MSI) in a population-based study of FIGO stage 1-4 endometrial endometrioid adenocarcinomas. Study Design: Survival analysis in 273 patients of MSI status and clinico-pathologic features. Using a highly sensitive pentaplex polymerase chain reaction to establish MSI status, cases were divided into microsatellite stable (MSS), MSI-low (MSI-L, 1 marker positive) and MSI-high (MSI-H, 2-5 markers positive).

Original language	English
Pages (from-to)	457-65
Number of pages	9
Journal	Cellular Oncology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/s13402-011-0040-x
Publication status	Published - Oct 2011

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title = "High frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases",

abstract = "To analyze the prognostic value of microsatellite instability (MSI) in a population-based study of FIGO stage 1-4 endometrial endometrioid adenocarcinomas. Study Design: Survival analysis in 273 patients of MSI status and clinico-pathologic features. Using a highly sensitive pentaplex polymerase chain reaction to establish MSI status, cases were divided into microsatellite stable (MSS), MSI-low (MSI-L, 1 marker positive) and MSI-high (MSI-H, 2-5 markers positive).",

author = "Anita Steinbakk and Anais Malpica and Aida Slewa and Einar Gudlaugsson and Janssen, \{Emiel A M\} and Mark Arends and Kruse, \{Arnold Jan\} and Yu Yinhua and Weiwei Feng and Baak, \{Jan P\}",

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doi = "10.1007/s13402-011-0040-x",

language = "English",

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T1 - High frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases

AU - Steinbakk, Anita

AU - Malpica, Anais

AU - Slewa, Aida

AU - Gudlaugsson, Einar

AU - Janssen, Emiel A M

AU - Arends, Mark

AU - Kruse, Arnold Jan

AU - Yinhua, Yu

AU - Feng, Weiwei

AU - Baak, Jan P

PY - 2011/10

Y1 - 2011/10

N2 - To analyze the prognostic value of microsatellite instability (MSI) in a population-based study of FIGO stage 1-4 endometrial endometrioid adenocarcinomas. Study Design: Survival analysis in 273 patients of MSI status and clinico-pathologic features. Using a highly sensitive pentaplex polymerase chain reaction to establish MSI status, cases were divided into microsatellite stable (MSS), MSI-low (MSI-L, 1 marker positive) and MSI-high (MSI-H, 2-5 markers positive).

AB - To analyze the prognostic value of microsatellite instability (MSI) in a population-based study of FIGO stage 1-4 endometrial endometrioid adenocarcinomas. Study Design: Survival analysis in 273 patients of MSI status and clinico-pathologic features. Using a highly sensitive pentaplex polymerase chain reaction to establish MSI status, cases were divided into microsatellite stable (MSS), MSI-low (MSI-L, 1 marker positive) and MSI-high (MSI-H, 2-5 markers positive).

U2 - 10.1007/s13402-011-0040-x

DO - 10.1007/s13402-011-0040-x

M3 - Article

C2 - 21547578

SN - 2211-3436

VL - 34

SP - 457

EP - 465

JO - Cellular Oncology

JF - Cellular Oncology

IS - 5

ER -

High frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases

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