High-Precision Photothermal Ablation using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy

Belén Rubio Ruiz, Ana M. Pérez-López, Thomas L. Bray, Martin Lee, Alan Serrels, Martin Prieto, Manuel Arruebo, Neil O. Carragher, Víctor Sebastián, Asier Unciti-Broceta

Research output: Contribution to journalArticlepeer-review

Abstract

Herein we report a straightforward method for the scalable preparation of Pd nanoparticles (Pd-NPs) with reduced inherent cytotoxicity and high photothermal conversion capacity. These Pd-NPs are rapidly taken up by cells and able to kill labelled cancer cells upon short exposure to near infrared (NIR) light. Following cell treatment with Pd-NPs, ablated areas were patterned with high precision by laser scanning microscopy, allowing to perform cell migration assays with unprecedented accuracy. Using coherent Raman microscopy, cells containing Pd-NPs were simultaneously ablated and imaged. This novel methodology was combined with intravital imaging to mediate micro-ablation of cancerous tissue in tumour xenografts in mice.

Original languageEnglish
JournalACS Applied Materials & Interfaces
Early online date10 Jan 2018
DOIs
Publication statusE-pub ahead of print - 10 Jan 2018

Keywords

  • Journal Article

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