High-pressure polymorphism in amino acids

Stephen A. Moggach, Simon Parsons, Peter A. Wood

Research output: Contribution to journalArticlepeer-review


Pressure up to 10 GPa is a powerful method for studying polymorphism in organic crystal structures, and this review surveys work carried out on high-pressure polymorphism in amino acids. High-pressure polymorphs have been established crystallographically for glycine, alanine, serine, cysteine and leucine. Phase transitions can be driven by the avoidance of very short intermolecular contacts or by promotion of a more stable molecular conformation. Experimental methods are also briefly surveyed, along with three methods that have proved very helpful in the analysis of high-pressure polymorphs, namely the PIXEL method for calculation of intermolecular energies, topological analysis with Voronoi-Dirichlet partitioning and Hirshfeld surfaces for gaining a graphical overview of intermolecular interactions.

Original languageEnglish
Pages (from-to)143-183
Number of pages41
JournalCrystallography reviews
Issue number2
Publication statusPublished - 2008


Dive into the research topics of 'High-pressure polymorphism in amino acids'. Together they form a unique fingerprint.

Cite this