High-pressure structural studies of the pharmaceutical, chlorothiazide

Iain D. H. Oswald; Alistair R. Lennie; Colin R. Pulham; Kenneth Shankland

doi:10.1039/c001355b

High-pressure structural studies of the pharmaceutical, chlorothiazide

Iain D. H. Oswald, Alistair R. Lennie, Colin R. Pulham, Kenneth Shankland

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.

Original language	English
Pages (from-to)	2533-2540
Number of pages	8
Journal	CrystEngComm
Volume	12
Issue number	9
DOIs	https://doi.org/10.1039/c001355b
Publication status	Published - 2010

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AU - Lennie, Alistair R.

AU - Pulham, Colin R.

AU - Shankland, Kenneth

PY - 2010

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DO - 10.1039/c001355b

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SP - 2533

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JO - CrystEngComm

JF - CrystEngComm

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High-pressure structural studies of the pharmaceutical, chlorothiazide

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