High-pressure structural studies of the pharmaceutical, chlorothiazide

Iain D. H. Oswald, Alistair R. Lennie, Colin R. Pulham, Kenneth Shankland

Research output: Contribution to journalArticlepeer-review


The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.

Original languageEnglish
Pages (from-to)2533-2540
Number of pages8
Issue number9
Publication statusPublished - 2010


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