Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

Nicolaos Avlonitis, Manuelle Debunne, Tashfeen Aslam, Neil McDonald, Chris Haslett, Kevin Dhaliwal, Mark Bradley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases.

Original languageEnglish
Pages (from-to)4414-4418
Number of pages5
JournalOrganic & Biomolecular chemistry
Volume11
Issue number26
DOIs
Publication statusPublished - 14 Jul 2013

Keywords

  • CATHEPSIN-G
  • PROTEINASE-3
  • ENHANCEMENT
  • DENDRIMERS

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