TY - JOUR
T1 - Hippo-Yap/Taz signalling in zebrafish regeneration
AU - Riley, Susanna E.
AU - Feng, Yi
AU - Hansen, Carsten Gram
N1 - Funding Information:
Work ongoing in the Gram Hansen lab is supported by a University of Edinburgh Chancellor’s Fellowship as well as by Worldwide Cancer Research (19-0238) and LifeArc-CSO. Additional funding has been obtained from the Bone Cancer Research Trust (BCRT), Sarcoma UK (SUK202.2016), the Wellcome Trust-University of Edinburgh Institutional Strategic Support Fund (ISSF3). Y.F. received a Wellcome Trust Sir Henry Dale Fellowship (100104/Z/12/Z); Cancer Research UK early detection project award (C38363/A26931) and a Cancer Research UK pioneering award (C38363/A25107). S.E.R. is funded by a Wellcome Trust PhD studentship [108906/Z/15/Z]. Figures, besides Fig. 1, created in Adobe Illustrator.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/1/27
Y1 - 2022/1/27
N2 - The extent of tissue regeneration varies widely between species. Mammals have a limited regenerative capacity whilst lower vertebrates such as the zebrafish (Danio rerio), a freshwater teleost, can robustly regenerate a range of tissues, including the spinal cord, heart, and fin. The molecular and cellular basis of this altered response is one of intense investigation. In this review, we summarise the current understanding of the association between zebrafish regeneration and Hippo pathway function, a phosphorylation cascade that regulates cell proliferation, mechanotransduction, stem cell fate, and tumorigenesis, amongst others. We also compare this function to Hippo pathway activity in the regenerative response of other species. We find that the Hippo pathway effectors Yap/Taz facilitate zebrafish regeneration and that this appears to be latent in mammals, suggesting that therapeutically promoting precise and temporal YAP/TAZ signalling in humans may enhance regeneration and hence reduce morbidity.
AB - The extent of tissue regeneration varies widely between species. Mammals have a limited regenerative capacity whilst lower vertebrates such as the zebrafish (Danio rerio), a freshwater teleost, can robustly regenerate a range of tissues, including the spinal cord, heart, and fin. The molecular and cellular basis of this altered response is one of intense investigation. In this review, we summarise the current understanding of the association between zebrafish regeneration and Hippo pathway function, a phosphorylation cascade that regulates cell proliferation, mechanotransduction, stem cell fate, and tumorigenesis, amongst others. We also compare this function to Hippo pathway activity in the regenerative response of other species. We find that the Hippo pathway effectors Yap/Taz facilitate zebrafish regeneration and that this appears to be latent in mammals, suggesting that therapeutically promoting precise and temporal YAP/TAZ signalling in humans may enhance regeneration and hence reduce morbidity.
U2 - 10.1038/s41536-022-00209-8
DO - 10.1038/s41536-022-00209-8
M3 - Review article
SN - 2057-3995
VL - 7
JO - npj Regenerative Medicine
JF - npj Regenerative Medicine
IS - 1
ER -