HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia

Mandy Johnstone; Rana Fetit

doi:10.1016/j.stem.2018.04.008

HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia

Mandy Johnstone, Rana Fetit

Research output: Contribution to journal › Literature review

Abstract

In this issue of Cell Stem Cell, Sarkar et al. (2018) describe an efficient method for the generation of human hippocampal pyramidal neurons from stem cells. They developed a compelling in vitro model that recapitulates synaptic connectivity within the hippocampus and showed that cells derived from patients with schizophrenia exhibit abnormal electrical activity.

Original language	English
Pages (from-to)	609-611
Number of pages	3
Journal	Cell Stem Cell
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2018.04.008
Publication status	Published - 3 May 2018

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abstract = "In this issue of Cell Stem Cell, Sarkar et al. (2018) describe an efficient method for the generation of human hippocampal pyramidal neurons from stem cells. They developed a compelling in vitro model that recapitulates synaptic connectivity within the hippocampus and showed that cells derived from patients with schizophrenia exhibit abnormal electrical activity.",

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HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia

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