Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936

Maria del Carmen  Valdés Hernández; Simon R. Cox; Jaeil Kim; Natalie A. Royle; Susana Muñoz Maniega; Alan Gow; Devasuda Anblagan; Mark E. Bastin; Jinah Park; John M. Starr; Joanna M. Wardlaw; Ian J. Deary

doi:10.1016/j.neurobiolaging.2016.12.012

Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936

Maria del Carmen Valdés Hernández, Simon R. Cox, Jaeil Kim, Natalie A. Royle, Susana Muñoz Maniega, Alan Gow, Devasuda Anblagan, Mark E. Bastin, Jinah Park, John M. Starr, Joanna M. Wardlaw, Ian J. Deary

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Structural measures of the hippocampus have been linked to a variety of memory processes and also to broader cognitive abilities. Gross volumetry has been widely used, yet the hippocampus has a complex formation, comprising distinct subfields which may be differentially sensitive to the deleterious effects of age, and to different aspects of cognitive performance. However, a comprehensive analysis of multidomain cognitive associations with hippocampal deformations among a large group of cognitively normal older adults is currently lacking. In 654 participants of the Lothian Birth Cohort 1936 (mean age = 72.5, SD = 0.71 years), we examined associations between the morphology of the hippocampus and a variety of memory tests (spatial span, letter-number sequencing, verbal recall, and digit backwards), as well as broader cognitive domains (latent measures of speed, fluid intelligence, and memory). Following correction for age, sex, and vascular risk factors, analysis of memory subtests revealed that only right hippocampal associations in relation to spatial memory survived type 1 error correction in subiculum and in CA1 at the head (β = 0.201, p = 5.843 × 10−4, outward), and in the ventral tail section of CA1 (β = −0.272, p = 1.347 × 10−5, inward). With respect to latent measures of cognitive domains, only deformations associated with processing speed survived type 1 error correction in bilateral subiculum (βabsolute ≤ 0.247, p < 1.369 × 10⁻⁴, outward), bilaterally in the ventral tail section of CA1 (βabsolute ≤ 0.242, p < 3.451 × ¹⁰⁻⁶, inward), and a cluster at the left anterior-to-dorsal region of the head (β = 0.199, p = 5.220 × 10₋₆, outward). Overall, our results indicate that a complex pattern of both inward and outward hippocampal deformations are associated with better processing speed and spatial memory in older age, suggesting that complex shape-based hippocampal analyses may provide valuable information beyond gross volumetry.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Neurobiology of Aging
Volume	52
Early online date	21 Dec 2016
DOIs	https://doi.org/10.1016/j.neurobiolaging.2016.12.012
Publication status	Published - 30 Apr 2017

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10.1016/j.neurobiolaging.2016.12.012Licence: Creative Commons: Attribution (CC-BY)

1-s2.0-S0197458016303189-mainFinal published version, 2.28 MBLicence: Creative Commons: Attribution (CC-BY)

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Development of computational models for characterising atrophy of subcortical brain structures and ventricles
Valdes Hernandez, M., Park, J. & Wardlaw, J.
1/09/12 → 31/08/14
Project: Research Collaboration with external organisation

Maria Valdes Hernandez
- Deanery of Clinical Sciences - Lecturer in Medical Image Analysis
- Centre for Clinical Brain Sciences
- Edinburgh Neuroscience
- Edinburgh Imaging
- Small Vessel Disease Research
Person: Academic: Research Active , Academic: Research Active (Research Assistant)

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Valdés Hernández, M. D. C., Cox, S. R., Kim, J., Royle, N. A., Muñoz Maniega, S., Gow, A., Anblagan, D., Bastin, M. E., Park, J., Starr, J. M., Wardlaw, J. M., & Deary, I. J. (2017). Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936. Neurobiology of Aging, 52, 1-11. https://doi.org/10.1016/j.neurobiolaging.2016.12.012

@article{3874cfb438e544a79d5876264a01dbe6,

title = "Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936",

abstract = "Structural measures of the hippocampus have been linked to a variety of memory processes and also to broader cognitive abilities. Gross volumetry has been widely used, yet the hippocampus has a complex formation, comprising distinct subfields which may be differentially sensitive to the deleterious effects of age, and to different aspects of cognitive performance. However, a comprehensive analysis of multidomain cognitive associations with hippocampal deformations among a large group of cognitively normal older adults is currently lacking. In 654 participants of the Lothian Birth Cohort 1936 (mean age = 72.5, SD = 0.71 years), we examined associations between the morphology of the hippocampus and a variety of memory tests (spatial span, letter-number sequencing, verbal recall, and digit backwards), as well as broader cognitive domains (latent measures of speed, fluid intelligence, and memory). Following correction for age, sex, and vascular risk factors, analysis of memory subtests revealed that only right hippocampal associations in relation to spatial memory survived type 1 error correction in subiculum and in CA1 at the head (β = 0.201, p = 5.843 × 10−4, outward), and in the ventral tail section of CA1 (β = −0.272, p = 1.347 × 10−5, inward). With respect to latent measures of cognitive domains, only deformations associated with processing speed survived type 1 error correction in bilateral subiculum (βabsolute ≤ 0.247, p < 1.369 × 10−4, outward), bilaterally in the ventral tail section of CA1 (βabsolute ≤ 0.242, p < 3.451 × 10−6, inward), and a cluster at the left anterior-to-dorsal region of the head (β = 0.199, p = 5.220 × 10−6, outward). Overall, our results indicate that a complex pattern of both inward and outward hippocampal deformations are associated with better processing speed and spatial memory in older age, suggesting that complex shape-based hippocampal analyses may provide valuable information beyond gross volumetry.",

author = "{Vald{\'e}s Hern{\'a}ndez}, {Maria del Carmen} and Cox, {Simon R.} and Jaeil Kim and Royle, {Natalie A.} and {Mu{\~n}oz Maniega}, Susana and Alan Gow and Devasuda Anblagan and Bastin, {Mark E.} and Jinah Park and Starr, {John M.} and Wardlaw, {Joanna M.} and Deary, {Ian J.}",

note = "Date of Acceptance: 13/12/2016.",

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month = apr,

day = "30",

doi = "10.1016/j.neurobiolaging.2016.12.012",

language = "English",

volume = "52",

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TY - JOUR

T1 - Hippocampal morphology and cognitive functions in community-dwelling older people

T2 - the Lothian Birth Cohort 1936

AU - Valdés Hernández, Maria del Carmen

AU - Cox, Simon R.

AU - Kim, Jaeil

AU - Royle, Natalie A.

AU - Muñoz Maniega, Susana

AU - Gow, Alan

AU - Anblagan, Devasuda

AU - Bastin, Mark E.

AU - Park, Jinah

AU - Starr, John M.

AU - Wardlaw, Joanna M.

AU - Deary, Ian J.

N1 - Date of Acceptance: 13/12/2016.

PY - 2017/4/30

Y1 - 2017/4/30

N2 - Structural measures of the hippocampus have been linked to a variety of memory processes and also to broader cognitive abilities. Gross volumetry has been widely used, yet the hippocampus has a complex formation, comprising distinct subfields which may be differentially sensitive to the deleterious effects of age, and to different aspects of cognitive performance. However, a comprehensive analysis of multidomain cognitive associations with hippocampal deformations among a large group of cognitively normal older adults is currently lacking. In 654 participants of the Lothian Birth Cohort 1936 (mean age = 72.5, SD = 0.71 years), we examined associations between the morphology of the hippocampus and a variety of memory tests (spatial span, letter-number sequencing, verbal recall, and digit backwards), as well as broader cognitive domains (latent measures of speed, fluid intelligence, and memory). Following correction for age, sex, and vascular risk factors, analysis of memory subtests revealed that only right hippocampal associations in relation to spatial memory survived type 1 error correction in subiculum and in CA1 at the head (β = 0.201, p = 5.843 × 10−4, outward), and in the ventral tail section of CA1 (β = −0.272, p = 1.347 × 10−5, inward). With respect to latent measures of cognitive domains, only deformations associated with processing speed survived type 1 error correction in bilateral subiculum (βabsolute ≤ 0.247, p < 1.369 × 10−4, outward), bilaterally in the ventral tail section of CA1 (βabsolute ≤ 0.242, p < 3.451 × 10−6, inward), and a cluster at the left anterior-to-dorsal region of the head (β = 0.199, p = 5.220 × 10−6, outward). Overall, our results indicate that a complex pattern of both inward and outward hippocampal deformations are associated with better processing speed and spatial memory in older age, suggesting that complex shape-based hippocampal analyses may provide valuable information beyond gross volumetry.

AB - Structural measures of the hippocampus have been linked to a variety of memory processes and also to broader cognitive abilities. Gross volumetry has been widely used, yet the hippocampus has a complex formation, comprising distinct subfields which may be differentially sensitive to the deleterious effects of age, and to different aspects of cognitive performance. However, a comprehensive analysis of multidomain cognitive associations with hippocampal deformations among a large group of cognitively normal older adults is currently lacking. In 654 participants of the Lothian Birth Cohort 1936 (mean age = 72.5, SD = 0.71 years), we examined associations between the morphology of the hippocampus and a variety of memory tests (spatial span, letter-number sequencing, verbal recall, and digit backwards), as well as broader cognitive domains (latent measures of speed, fluid intelligence, and memory). Following correction for age, sex, and vascular risk factors, analysis of memory subtests revealed that only right hippocampal associations in relation to spatial memory survived type 1 error correction in subiculum and in CA1 at the head (β = 0.201, p = 5.843 × 10−4, outward), and in the ventral tail section of CA1 (β = −0.272, p = 1.347 × 10−5, inward). With respect to latent measures of cognitive domains, only deformations associated with processing speed survived type 1 error correction in bilateral subiculum (βabsolute ≤ 0.247, p < 1.369 × 10−4, outward), bilaterally in the ventral tail section of CA1 (βabsolute ≤ 0.242, p < 3.451 × 10−6, inward), and a cluster at the left anterior-to-dorsal region of the head (β = 0.199, p = 5.220 × 10−6, outward). Overall, our results indicate that a complex pattern of both inward and outward hippocampal deformations are associated with better processing speed and spatial memory in older age, suggesting that complex shape-based hippocampal analyses may provide valuable information beyond gross volumetry.

U2 - 10.1016/j.neurobiolaging.2016.12.012

DO - 10.1016/j.neurobiolaging.2016.12.012

M3 - Article

C2 - 28104542

SN - 0197-4580

VL - 52

SP - 1

EP - 11

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936

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Projects

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Development of computational models for characterising atrophy of subcortical brain structures and ventricles

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Maria Valdes Hernandez

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