Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia

Anna Mckeever, Alvar F. Paris, James Cullen, Lawrence Hayes, Craig W. Ritchie, Karen Ritchie, Adam D. Waldman, Katie Wells, Albert Busza, Isabelle Carriere, John T. O’brien, Li Su

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background:Alzheimer’s disease (AD) begins decades before the onset of dementia. There is a need to investigate biomarkers of early AD for use in clinical trials and to facilitate early intervention. Objective:We aimed to determine whether changes in hippocampal subfield volumes in healthy middle-aged adults were associated with risk of future dementia. Methods:We included 150 participants from the PREVENT-Dementia cohort, which recruited subjects aged 40–59 with or without a family history of dementia (FHD; included here were 81 with FHD and 69 without). Hippocampal subfield volumes were segmented from high resolution T2-weighted 3T MRI images taken at baseline and 2-year follow-up. Results:FHD and greater 20 year-risk of dementia due to cardiovascular risk factors were both associated with lower CA1 volume. FHD was also associated with a relative increase in combined CA3, CA4, and dentate gyrus volume between baseline and follow-up. Conclusion:CA1 atrophy may commence as early as middle-age in those with a high risk of future dementia, while increases in CA3, CA4, and dentate gyrus volume may be a response to early AD in the form of inflammation or neurogenesis.
Original languageEnglish
Pages (from-to)1211-1218
Number of pages8
JournalJournal of Alzheimer's Disease
Issue number4
Publication statusPublished - 11 May 2020


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