HiSNAP trial—a multicentre, randomised, open-label, blinded end point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 600 mg/kg) in patients with paracetamol overdose in the UK: Study protocol

HiSNAP Trial Investigators, Christopher Humphries, Ellise Clarke, Michael Eddleston, Marianne Gillings, Sian Irvine, Liza Keating, Anna Miell, Lynsey Milne, Laura Muir, Rachel O'Brien, Katherine Oatey, Rajendra Raman, Ruben Thanacoody, Sharon Tuck, Christopher J Weir, David M Wood, James W Dear*

*Corresponding author for this work

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Pharmacology, Toxicology and Pharmaceutical Science