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METHODS: Sixty-four SCLC biopsies were immunohistochemically stained with anti-CD45 antibody to identify immune cells associated with tumour. A mean CD45 count per high power field for each case was obtained and the results correlated with age, sex, stage, performance status (PS), treatment with chemotherapy / radiotherapy and overall survival.
RESULTS: The median CD45 count for all cases was taken as 40 (CD4540). Kaplan-Meier plots demonstrated better survival for patients with a CD4540 >40 (p<0.009). No relationship between CD4540 and age, sex , stage, treatment by chemotherapy or radiotherapy was identified. While PS was a significant predictor of survival (p=0.014) it did not correlate with CD4540. In patients with better ECOG performance status (PS ≤ 2) the CD4540 demonstrated a highly significant survival advantage for those with CD4540 >40 (p<0.0001).
CONCLUSIONS: The data indicate that a) simple immunohistochemical assessment of immune cell infiltrates in routinely processed and stained biopsies of primary tumours can provide prognostic information in SCLC; and, b) tumour associated CD45+ cells in SCLC biopsies may be a good clinical marker to identify patients with poor prognosis despite good PS.
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- 1 Finished
1/09/12 → 31/08/16