Histological assessment of β-amyloid precursor protein immunolabelled rectal biopsies aids diagnosis of equine grass sickness

R. C. Jago; S. Scholes; T. S. Mair; G. R. Pearson; R. S. Pirie; I. Handel; E. M. Milne; F. Coyle; B. C. McGorum

doi:10.1111/evj.12710

Histological assessment of β-amyloid precursor protein immunolabelled rectal biopsies aids diagnosis of equine grass sickness

R. C. Jago, S. Scholes, T. S. Mair, G. R. Pearson, R. S. Pirie, I. Handel, E. M. Milne, F. Coyle, B. C. McGorum

Research output: Contribution to journal › Article › peer-review

Abstract

An accurate, minimally invasive, ante-mortem, diagnostic test for equine grass sickness 42 (EGS) is currently lacking. While histological examination of haematoxylin-eosin stained rectal biopsies 43 for chromatolytic neurons is insensitive as a diagnostic test for EGS, it was hypothesised that the 44 diagnostic accuracy could be improved by immunolabelling for β-amyloid precursor protein (β-APP) 45 which has increased expression in cranial cervical ganglia (CCG) neuronal perikarya in EGS.

Original language	English
Pages (from-to)	22-28
Journal	Equine Veterinary Journal
Volume	50
Issue number	1
Early online date	16 Jun 2017
DOIs	https://doi.org/10.1111/evj.12710
Publication status	Published - Jan 2018

Keywords / Materials (for Non-textual outputs)

horse
grass sickness
dysautonomia
neurodegeneration
rectal biopsy
β-amyloid
precursor protein

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10.1111/evj.12710

Histological assessment of β-amyloid precursor protein immunolabelled rectal biopsies aids diagnosis of equine grass sicknessAccepted author manuscript, 666 KB

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title = "Histological assessment of β-amyloid precursor protein immunolabelled rectal biopsies aids diagnosis of equine grass sickness",

abstract = "An accurate, minimally invasive, ante-mortem, diagnostic test for equine grass sickness 42 (EGS) is currently lacking. While histological examination of haematoxylin-eosin stained rectal biopsies 43 for chromatolytic neurons is insensitive as a diagnostic test for EGS, it was hypothesised that the 44 diagnostic accuracy could be improved by immunolabelling for β-amyloid precursor protein (β-APP) 45 which has increased expression in cranial cervical ganglia (CCG) neuronal perikarya in EGS.",

keywords = "horse, grass sickness, dysautonomia, neurodegeneration, rectal biopsy, β-amyloid, precursor protein",

author = "Jago, {R. C.} and S. Scholes and Mair, {T. S.} and Pearson, {G. R.} and Pirie, {R. S.} and I. Handel and Milne, {E. M.} and F. Coyle and McGorum, {B. C.}",

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AU - Jago, R. C.

AU - Scholes, S.

AU - Mair, T. S.

AU - Pearson, G. R.

AU - Pirie, R. S.

AU - Handel, I.

AU - Milne, E. M.

AU - Coyle, F.

AU - McGorum, B. C.

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N2 - An accurate, minimally invasive, ante-mortem, diagnostic test for equine grass sickness 42 (EGS) is currently lacking. While histological examination of haematoxylin-eosin stained rectal biopsies 43 for chromatolytic neurons is insensitive as a diagnostic test for EGS, it was hypothesised that the 44 diagnostic accuracy could be improved by immunolabelling for β-amyloid precursor protein (β-APP) 45 which has increased expression in cranial cervical ganglia (CCG) neuronal perikarya in EGS.

AB - An accurate, minimally invasive, ante-mortem, diagnostic test for equine grass sickness 42 (EGS) is currently lacking. While histological examination of haematoxylin-eosin stained rectal biopsies 43 for chromatolytic neurons is insensitive as a diagnostic test for EGS, it was hypothesised that the 44 diagnostic accuracy could be improved by immunolabelling for β-amyloid precursor protein (β-APP) 45 which has increased expression in cranial cervical ganglia (CCG) neuronal perikarya in EGS.

KW - horse

KW - grass sickness

KW - dysautonomia

KW - neurodegeneration

KW - rectal biopsy

KW - β-amyloid

KW - precursor protein

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ER -

Histological assessment of β-amyloid precursor protein immunolabelled rectal biopsies aids diagnosis of equine grass sickness

Abstract

Keywords / Materials (for Non-textual outputs)

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