Histological assessment of β-amyloid precursor protein immunolabelled rectal biopsies aids diagnosis of equine grass sickness

Rachel Jago, Sandra Scholes, T. Mair, Gemma Pearson, Robert Pirie, Ian Handel, Elspeth Milne, f Coyle, Bruce McGorum

Research output: Contribution to journalArticlepeer-review

Abstract

An accurate, minimally invasive, ante-mortem, diagnostic test for equine grass sickness 42 (EGS) is currently lacking. While histological examination of haematoxylin-eosin stained rectal biopsies 43 for chromatolytic neurons is insensitive as a diagnostic test for EGS, it was hypothesised that the 44 diagnostic accuracy could be improved by immunolabelling for β-amyloid precursor protein (β-APP) 45 which has increased expression in cranial cervical ganglia (CCG) neuronal perikarya in EGS.
Original languageEnglish
Pages (from-to)22-28
JournalEquine Veterinary Journal
Volume50
Issue number1
Early online date16 Jun 2017
DOIs
Publication statusPublished - Jan 2018

Keywords

  • horse
  • grass sickness
  • dysautonomia
  • neurodegeneration
  • rectal biopsy
  • β-amyloid
  • precursor protein

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