Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Heather W Dolby, Philippe Potey, Annika B Wilder-Smith, Sara Clohisey, Jonathan E Millar, J Kenneth Baillie, David A Dorward, Christopher D Lucas, Clark D Russell

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n  =  455 patients), severe acute respiratory syndrome ([SARS] n  =  37), Middle East respiratory syndrome (n  =  2), adenovirus (n  =  34), and respiratory syncytial virus (n  =  30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

Original languageEnglish
Pages (from-to)ofaa640
JournalOpen forum infectious diseases
Volume8
Issue number2
DOIs
Publication statusPublished - 28 Dec 2020

Keywords

  • acute respiratory distress syndrome
  • influenza
  • SARS coronavirus
  • thrombosis
  • vasculitis

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