Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Heather W Dolby; Philippe Potey; Annika B Wilder-Smith; Sara Clohisey; Jonathan E Millar; J Kenneth Baillie; David A Dorward; Christopher D Lucas; Clark D Russell

doi:10.1093/ofid/ofaa640

Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Heather W Dolby, Philippe Potey, Annika B Wilder-Smith, Sara Clohisey, Jonathan E Millar, J Kenneth Baillie, David A Dorward, Christopher D Lucas, Clark D Russell

Research output: Contribution to journal › Article › peer-review

Abstract

Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

Original language	English
Pages (from-to)	ofaa640
Journal	Open forum infectious diseases
Volume	8
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofaa640
Publication status	Published - 28 Dec 2020

Keywords / Materials (for Non-textual outputs)

acute respiratory distress syndrome
influenza
SARS coronavirus
thrombosis
vasculitis

Access to Document

10.1093/ofid/ofaa640

ofaa640
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 153 KBLicence: Creative Commons: Attribution (CC-BY)

Cite this

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title = "Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases",

abstract = "Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.",

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note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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AU - Dolby, Heather W

AU - Potey, Philippe

AU - Wilder-Smith, Annika B

AU - Clohisey, Sara

AU - Millar, Jonathan E

AU - Baillie, J Kenneth

AU - Dorward, David A

AU - Lucas, Christopher D

AU - Russell, Clark D

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N2 - Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

AB - Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

KW - acute respiratory distress syndrome

KW - influenza

KW - SARS coronavirus

KW - thrombosis

KW - vasculitis

U2 - 10.1093/ofid/ofaa640

DO - 10.1093/ofid/ofaa640

M3 - Article

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SP - ofaa640

JO - Open forum infectious diseases

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ER -

Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Abstract

Keywords / Materials (for Non-textual outputs)

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