Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Heather W Dolby; Philippe Potey; Annika B Wilder-Smith; Sara Clohisey; Jonathan E Millar; J Kenneth Baillie; David A Dorward; Christopher D Lucas; Clark D Russell

doi:10.1093/ofid/ofaa640

Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Heather W Dolby, Philippe Potey, Annika B Wilder-Smith, Sara Clohisey, Jonathan E Millar, J Kenneth Baillie, David A Dorward, Christopher D Lucas, Clark D Russell

Research output: Contribution to journal › Article › peer-review

Abstract

Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

Original language	English
Pages (from-to)	ofaa640
Journal	Open forum infectious diseases
Volume	8
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofaa640
Publication status	Published - 28 Dec 2020

Keywords

acute respiratory distress syndrome
influenza
SARS coronavirus
thrombosis
vasculitis

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10.1093/ofid/ofaa640

ofaa640
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 153 KBLicence: Creative Commons: Attribution (CC-BY)

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Dolby, Heather W ; Potey, Philippe ; Wilder-Smith, Annika B ; Clohisey, Sara ; Millar, Jonathan E ; Baillie, J Kenneth ; Dorward, David A ; Lucas, Christopher D ; Russell, Clark D. / Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases. In: Open forum infectious diseases. 2020 ; Vol. 8, No. 2. pp. ofaa640.

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abstract = "Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.",

keywords = "acute respiratory distress syndrome, influenza, SARS coronavirus, thrombosis, vasculitis",

author = "Dolby, {Heather W} and Philippe Potey and Wilder-Smith, {Annika B} and Sara Clohisey and Millar, {Jonathan E} and Baillie, {J Kenneth} and Dorward, {David A} and Lucas, {Christopher D} and Russell, {Clark D}",

note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases. / Dolby, Heather W; Potey, Philippe; Wilder-Smith, Annika B; Clohisey, Sara; Millar, Jonathan E; Baillie, J Kenneth; Dorward, David A; Lucas, Christopher D ; Russell, Clark D.

In: Open forum infectious diseases, Vol. 8, No. 2, 28.12.2020, p. ofaa640.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

AU - Dolby, Heather W

AU - Potey, Philippe

AU - Wilder-Smith, Annika B

AU - Clohisey, Sara

AU - Millar, Jonathan E

AU - Baillie, J Kenneth

AU - Dorward, David A

AU - Lucas, Christopher D

AU - Russell, Clark D

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N2 - Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

AB - Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

KW - acute respiratory distress syndrome

KW - influenza

KW - SARS coronavirus

KW - thrombosis

KW - vasculitis

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DO - 10.1093/ofid/ofaa640

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SP - ofaa640

JO - Open forum infectious diseases

JF - Open forum infectious diseases

SN - 2328-8957

IS - 2

ER -

Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

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Keywords

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