Histological Identification of Sequestered Parasitized Red Cells

Danny Arnold Milner, Ian James Callum MacCormick*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract / Description of output

The performance of complete post-mortem examinations of children with severe malaria has helped to explain the cause of death in cerebral malaria as well as show the global phenomenon of sequestration in tissues throughout the body, beyond the brain and eye. The pathology of the brain and other organs has been well described and shows a systemic disease with the most catastrophic features found in the brain (i.e., fatal cerebral edema).This chapter describes the materials and methods needed to study the pathological features of tissues outside of the eye, including the brain and other organs. The bulk of these techniques are standard to pathology including gross examination, histology, special stains, and immunohistochemistry.

Original languageEnglish
Title of host publication Malaria Immunology
Subtitle of host publicationTargeting the Surface of Infected Erythrocytes
EditorsAnja Tatiana Ramstedt Jensen, Lars Hviid
Place of PublicationNew York, NY
Pages779-791
Number of pages13
Volume2470
ISBN (Electronic)9781071621899
DOIs
Publication statusPublished - 27 Jul 2022

Publication series

NameMethods in molecular biology (Clifton, N.J.)
PublisherHumana Press
ISSN (Print)1064-3745

Keywords / Materials (for Non-textual outputs)

  • Autopsy
  • Brain/pathology
  • Child
  • Erythrocytes/pathology
  • Humans
  • Immunohistochemistry
  • Malaria, Cerebral

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