Histological spectrum of malignant melanoma

T Brenn

Research output: Contribution to journalArticlepeer-review


The diagnosis of melanocytic tumors is one of the most problematic areas in dermatology and diagnostic pathology. Melanoma is a malignant melanocytic tumor and the risk for metastasis and associated mortality is mainly dependent on tumor thickness and depth of invasion. Early recognition and correct diagnosis is therefore important for successful and effective treatment. The correct diagnosis of melanoma is, however, challenging due to the wide morphological spectrum. Historically, the disease was subdivided into superficial spreading, nodular, lentigo maligna and acral lentiginous melanoma but many more subtypes have subsequently been added. Some of these melanoma variants also show differences relating to the genetic background, clinical presentation, prognosis and treatment and may be associated with a specific differential diagnosis. In this article four of these melanoma variants, desmoplastic melanoma, nevoid melanoma, malignant blue nevus and pigment synthesizing melanoma will be discussed in more detail.

Translated title of the contributionHistological spectrum of malignant melanoma
Original languageGerman
Pages (from-to)53-61
Number of pages9
JournalDer Pathologe
Issue number1
Publication statusPublished - Feb 2015


  • Adult
  • Aged
  • Diagnosis, Differential
  • Humans
  • Lymph Nodes
  • Melanoma
  • Middle Aged
  • Neoplasm Invasiveness
  • Prognosis
  • Sentinel Lymph Node Biopsy
  • Skin
  • Skin Neoplasms
  • Tumor Burden

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