Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression

Kenji Inoue; Mika Kobayashi; Kiichiro Yano; Mai Miura; Akashi Izumi; Chikage Mataki; Takeshi Doi; Takao Hamakubo; Patrick C Reid; David A Hume; Minoru Yoshida; William C Aird; Tatsuhiko Kodama; Takashi Minami

doi:10.1161/01.ATV.0000247247.89787.e7

Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression

Kenji Inoue, Mika Kobayashi, Kiichiro Yano, Mai Miura, Akashi Izumi, Chikage Mataki, Takeshi Doi, Takao Hamakubo, Patrick C Reid, David A Hume, Minoru Yoshida, William C Aird, Tatsuhiko Kodama, Takashi Minami

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor necrosis factor (TNF)-alpha initiates numerous changes in endothelial cell (EC) gene expression that contributes to the pathology of various diseases including inflammation. We hypothesized that TNF-alpha-mediated gene induction involves multiple signaling pathways, and that inhibition of one or more of these pathways may selectively target subsets of TNF-alpha-responsive genes and functions.

Original language	English
Pages (from-to)	2652-9
Number of pages	8
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	26
Issue number	12
DOIs	https://doi.org/10.1161/01.ATV.0000247247.89787.e7
Publication status	Published - Dec 2006

Keywords

Animals
Azepines
Cell Adhesion
Chromones
E-Selectin
Endothelium, Vascular
Enzyme Inhibitors
Gene Expression Regulation
Histone Deacetylase Inhibitors
Histone Deacetylases
Humans
Hydroxamic Acids
Intercellular Adhesion Molecule-1
Leupeptins
Mice
Mice, Transgenic
Monocytes
Morpholines
RNA, Messenger
Signal Transduction
Transcriptional Activation
Tumor Necrosis Factor-alpha
Vascular Cell Adhesion Molecule-1

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10.1161/01.ATV.0000247247.89787.e7

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Inoue, K., Kobayashi, M., Yano, K., Miura, M., Izumi, A., Mataki, C., Doi, T., Hamakubo, T., Reid, P. C., Hume, D. A., Yoshida, M., Aird, W. C., Kodama, T., & Minami, T. (2006). Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(12), 2652-9. https://doi.org/10.1161/01.ATV.0000247247.89787.e7

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title = "Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression",

abstract = "Tumor necrosis factor (TNF)-alpha initiates numerous changes in endothelial cell (EC) gene expression that contributes to the pathology of various diseases including inflammation. We hypothesized that TNF-alpha-mediated gene induction involves multiple signaling pathways, and that inhibition of one or more of these pathways may selectively target subsets of TNF-alpha-responsive genes and functions.",

keywords = "Animals, Azepines, Cell Adhesion, Chromones, E-Selectin, Endothelium, Vascular, Enzyme Inhibitors, Gene Expression Regulation, Histone Deacetylase Inhibitors, Histone Deacetylases, Humans, Hydroxamic Acids, Intercellular Adhesion Molecule-1, Leupeptins, Mice, Mice, Transgenic, Monocytes, Morpholines, RNA, Messenger, Signal Transduction, Transcriptional Activation, Tumor Necrosis Factor-alpha, Vascular Cell Adhesion Molecule-1",

author = "Kenji Inoue and Mika Kobayashi and Kiichiro Yano and Mai Miura and Akashi Izumi and Chikage Mataki and Takeshi Doi and Takao Hamakubo and Reid, {Patrick C} and Hume, {David A} and Minoru Yoshida and Aird, {William C} and Tatsuhiko Kodama and Takashi Minami",

year = "2006",

month = dec,

doi = "10.1161/01.ATV.0000247247.89787.e7",

language = "English",

volume = "26",

pages = "2652--9",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott Williams & Wilkins",

number = "12",

}

Inoue, K, Kobayashi, M, Yano, K, Miura, M, Izumi, A, Mataki, C, Doi, T, Hamakubo, T, Reid, PC, Hume, DA, Yoshida, M, Aird, WC, Kodama, T & Minami, T 2006, 'Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 12, pp. 2652-9. https://doi.org/10.1161/01.ATV.0000247247.89787.e7

TY - JOUR

T1 - Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression

AU - Inoue, Kenji

AU - Kobayashi, Mika

AU - Yano, Kiichiro

AU - Miura, Mai

AU - Izumi, Akashi

AU - Mataki, Chikage

AU - Doi, Takeshi

AU - Hamakubo, Takao

AU - Reid, Patrick C

AU - Hume, David A

AU - Yoshida, Minoru

AU - Aird, William C

AU - Kodama, Tatsuhiko

AU - Minami, Takashi

PY - 2006/12

Y1 - 2006/12

N2 - Tumor necrosis factor (TNF)-alpha initiates numerous changes in endothelial cell (EC) gene expression that contributes to the pathology of various diseases including inflammation. We hypothesized that TNF-alpha-mediated gene induction involves multiple signaling pathways, and that inhibition of one or more of these pathways may selectively target subsets of TNF-alpha-responsive genes and functions.

AB - Tumor necrosis factor (TNF)-alpha initiates numerous changes in endothelial cell (EC) gene expression that contributes to the pathology of various diseases including inflammation. We hypothesized that TNF-alpha-mediated gene induction involves multiple signaling pathways, and that inhibition of one or more of these pathways may selectively target subsets of TNF-alpha-responsive genes and functions.

KW - Animals

KW - Azepines

KW - Cell Adhesion

KW - Chromones

KW - E-Selectin

KW - Endothelium, Vascular

KW - Enzyme Inhibitors

KW - Gene Expression Regulation

KW - Histone Deacetylase Inhibitors

KW - Histone Deacetylases

KW - Humans

KW - Hydroxamic Acids

KW - Intercellular Adhesion Molecule-1

KW - Leupeptins

KW - Mice

KW - Mice, Transgenic

KW - Monocytes

KW - Morpholines

KW - RNA, Messenger

KW - Signal Transduction

KW - Transcriptional Activation

KW - Tumor Necrosis Factor-alpha

KW - Vascular Cell Adhesion Molecule-1

U2 - 10.1161/01.ATV.0000247247.89787.e7

DO - 10.1161/01.ATV.0000247247.89787.e7

M3 - Article

C2 - 17008592

VL - 26

SP - 2652

EP - 2659

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 12

ER -

Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression

Abstract

Keywords

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