Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression

Kenji Inoue, Mika Kobayashi, Kiichiro Yano, Mai Miura, Akashi Izumi, Chikage Mataki, Takeshi Doi, Takao Hamakubo, Patrick C Reid, David A Hume, Minoru Yoshida, William C Aird, Tatsuhiko Kodama, Takashi Minami

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Tumor necrosis factor (TNF)-alpha initiates numerous changes in endothelial cell (EC) gene expression that contributes to the pathology of various diseases including inflammation. We hypothesized that TNF-alpha-mediated gene induction involves multiple signaling pathways, and that inhibition of one or more of these pathways may selectively target subsets of TNF-alpha-responsive genes and functions.
Original languageEnglish
Pages (from-to)2652-9
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 2006

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Azepines
  • Cell Adhesion
  • Chromones
  • E-Selectin
  • Endothelium, Vascular
  • Enzyme Inhibitors
  • Gene Expression Regulation
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • Humans
  • Hydroxamic Acids
  • Intercellular Adhesion Molecule-1
  • Leupeptins
  • Mice
  • Mice, Transgenic
  • Monocytes
  • Morpholines
  • RNA, Messenger
  • Signal Transduction
  • Transcriptional Activation
  • Tumor Necrosis Factor-alpha
  • Vascular Cell Adhesion Molecule-1

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