Histone macroH2A isoforms predict the risk of lung cancer recurrence

J. C. Sporn; G. Kustatscher; T. Hothorn; M. Collado; M. Serrano; T. Muley; P. Schnabel; A. G. Ladurner

doi:10.1038/onc.2009.26

Histone macroH2A isoforms predict the risk of lung cancer recurrence

J. C. Sporn, G. Kustatscher, T. Hothorn, M. Collado, M. Serrano, T. Muley, P. Schnabel, A. G. Ladurner

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumor recurrence. Here, we show that expression of histone macroH2A1.1 and macroH2A2 predicts lung cancer recurrence, identifying these histone variants as a novel tool for an improved risk stratification of cancer patients. Moreover, macroH2A isoforms are highly expressed in cells undergoing senescence, a known antitumor mechanism, suggesting macroH2A1.1 may be a useful biomarker for senescent cells in tumors.

Original language	English
Pages (from-to)	3423-3428
Number of pages	6
Journal	Oncogene
Volume	28
Issue number	38
DOIs	https://doi.org/10.1038/onc.2009.26
Publication status	Published - 24 Sept 2009

Keywords / Materials (for Non-textual outputs)

Cancer
Chromatin
Epigenetics
Metabolism
PARP
Proliferation

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10.1038/onc.2009.26

Cite this

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title = "Histone macroH2A isoforms predict the risk of lung cancer recurrence",

abstract = "Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumor recurrence. Here, we show that expression of histone macroH2A1.1 and macroH2A2 predicts lung cancer recurrence, identifying these histone variants as a novel tool for an improved risk stratification of cancer patients. Moreover, macroH2A isoforms are highly expressed in cells undergoing senescence, a known antitumor mechanism, suggesting macroH2A1.1 may be a useful biomarker for senescent cells in tumors.",

keywords = "Cancer, Chromatin, Epigenetics, Metabolism, PARP, Proliferation",

author = "Sporn, {J. C.} and G. Kustatscher and T. Hothorn and M. Collado and M. Serrano and T. Muley and P. Schnabel and Ladurner, {A. G.}",

note = "Funding Information: We thank Dr Esther Herpel for lung cancer tissue microarrays. AGL is supported by the EMBL, the NoE The Epigenome and the Marie Curie RTN Chromatin Plasticity. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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doi = "10.1038/onc.2009.26",

language = "English",

volume = "28",

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journal = "Oncogene",

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T1 - Histone macroH2A isoforms predict the risk of lung cancer recurrence

AU - Sporn, J. C.

AU - Kustatscher, G.

AU - Hothorn, T.

AU - Collado, M.

AU - Serrano, M.

AU - Muley, T.

AU - Schnabel, P.

AU - Ladurner, A. G.

N1 - Funding Information: We thank Dr Esther Herpel for lung cancer tissue microarrays. AGL is supported by the EMBL, the NoE The Epigenome and the Marie Curie RTN Chromatin Plasticity. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2009/9/24

Y1 - 2009/9/24

N2 - Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumor recurrence. Here, we show that expression of histone macroH2A1.1 and macroH2A2 predicts lung cancer recurrence, identifying these histone variants as a novel tool for an improved risk stratification of cancer patients. Moreover, macroH2A isoforms are highly expressed in cells undergoing senescence, a known antitumor mechanism, suggesting macroH2A1.1 may be a useful biomarker for senescent cells in tumors.

AB - Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumor recurrence. Here, we show that expression of histone macroH2A1.1 and macroH2A2 predicts lung cancer recurrence, identifying these histone variants as a novel tool for an improved risk stratification of cancer patients. Moreover, macroH2A isoforms are highly expressed in cells undergoing senescence, a known antitumor mechanism, suggesting macroH2A1.1 may be a useful biomarker for senescent cells in tumors.

KW - Cancer

KW - Chromatin

KW - Epigenetics

KW - Metabolism

KW - PARP

KW - Proliferation

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SN - 0950-9232

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JO - Oncogene

JF - Oncogene

IS - 38

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Histone macroH2A isoforms predict the risk of lung cancer recurrence

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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