Histopathological challenges in assessing invasion in squamous, glandular neoplasia of the cervix

Awatif Al-Nafussi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Cervical carcinomas usually arise from dysplastic epithelium. Squamous cell carcinoma, the most common type, evolves from cervical intraepithelial neoplasia (CIN) while adenocarcinoma develops from cervical glandular intraepithelial neoplasia (CGIN). The diagnosis of frankly invasive disease does not create a diagnostic problem. In contrast, confident diagnosis of the earliest stage of invasive disease arising from a dysplastic precursor lesion is problematic. The diagnostic process is further complicated by a lack of concordance concerning the nature (and behaviour) of certain diseases associated with the cervix e.g. CIN3-like squamous carcinoma, papillary squamo-transitional cell carcinoma, minimal deviation adenocarcinoma, adenoid basal carcinoma and microcystic adenocarcinoma. In this mini-symposium, an attempt has been made to clarify the features that are suggestive of definitive stromal invasion and to highlight the features of those unusual carcinomas that are often misinterpreted as non-invasive disease.

Original languageEnglish
Pages (from-to)364-393
Number of pages30
JournalCurrent Diagnostic Pathology
Issue number5
Publication statusPublished - 1 Oct 2006

Keywords / Materials (for Non-textual outputs)

  • Adenocarcinomas
  • Carcinomas
  • Cervix
  • CGIN
  • CIN
  • Microinvasive carcinomas
  • Squamous carcinoma


Dive into the research topics of 'Histopathological challenges in assessing invasion in squamous, glandular neoplasia of the cervix'. Together they form a unique fingerprint.

Cite this