HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

Selena Alonso, Marta Vidal, Gemma Ruiz-Olalla, Raquel González, Chenjerai Jairoce, M. Nelia Manaca, Miquel Vázquez-Santiago, Reyes Balcells, Anifa Vala, María Ruperez, Pau Cisteró, Laura Fuente-Soro, Evelina Angov, Ross L. Coppel, Benoit Gamain, David Cavanagh, James G. Beeson, Arsenio Nhacolo, Esperança Sevene, John J. AponteEusébio Macete, Ruth Aguilar, Alfredo Mayor, Clara Menéndez, Carlota Dobaño, Gemma Moncunill

Research output: Contribution to journalArticlepeer-review


Maternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses.

In a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens: Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (EXP1), merozoite surface proteins 1, 2 and 5, and reticulocyte-binding-homologue-4.2 (Rh4.2). We performed univariable and multivariable regression models to assess the association of maternal HIV infection, placental malaria, maternal variables and pregnancy outcomes on cord antibody levels and antibody transplacental transfer.

Maternal antibody levels were the main determinants of cord antibody levels. HIV infection and placental malaria reduced the transfer and cord levels of IgG and IgG1, and this was antigen-dependent. Low birth weight was associated with an increase of IgG2 in cord against EXP1 and Rh4.2.
Original languageEnglish
Pages (from-to)45-57
Number of pages13
JournalJournal of Infection
Issue number4
Early online date22 Feb 2021
Publication statusPublished - 1 Apr 2021


  • maternal antibodies
  • cord blood antibodies
  • placental transfer
  • HIV
  • placental malaria
  • IgG
  • IgG subclasses


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