HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

Selena Alonso; Marta Vidal; Gemma Ruiz-Olalla; Raquel González; Chenjerai Jairoce; M. Nelia Manaca; Miquel Vázquez-Santiago; Reyes Balcells; Anifa Vala; María Ruperez; Pau Cisteró; Laura Fuente-Soro; Evelina Angov; Ross L. Coppel; Benoit Gamain; David Cavanagh; James G. Beeson; Arsenio Nhacolo; Esperança Sevene; John J. Aponte; Eusébio Macete; Ruth Aguilar; Alfredo Mayor; Clara Menéndez; Carlota Dobaño; Gemma Moncunill

doi:10.1016/j.jinf.2021.02.024

HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

Selena Alonso, Marta Vidal, Gemma Ruiz-Olalla, Raquel González, Chenjerai Jairoce, M. Nelia Manaca, Miquel Vázquez-Santiago, Reyes Balcells, Anifa Vala, María Ruperez, Pau Cisteró, Laura Fuente-Soro, Evelina Angov, Ross L. Coppel, Benoit Gamain, David Cavanagh, James G. Beeson, Arsenio Nhacolo, Esperança Sevene, John J. AponteEusébio Macete, Ruth Aguilar, Alfredo Mayor, Clara Menéndez, Carlota Dobaño, Gemma Moncunill

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives
Maternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses.

Methods
In a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens: Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (EXP1), merozoite surface proteins 1, 2 and 5, and reticulocyte-binding-homologue-4.2 (Rh4.2). We performed univariable and multivariable regression models to assess the association of maternal HIV infection, placental malaria, maternal variables and pregnancy outcomes on cord antibody levels and antibody transplacental transfer.

Results
Maternal antibody levels were the main determinants of cord antibody levels. HIV infection and placental malaria reduced the transfer and cord levels of IgG and IgG1, and this was antigen-dependent. Low birth weight was associated with an increase of IgG2 in cord against EXP1 and Rh4.2.

Original language	English
Pages (from-to)	45-57
Number of pages	13
Journal	Journal of Infection
Volume	82
Issue number	4
Early online date	22 Feb 2021
DOIs	https://doi.org/10.1016/j.jinf.2021.02.024
Publication status	Published - 1 Apr 2021

Keywords

maternal antibodies
cord blood antibodies
placental transfer
HIV
placental malaria
IgG
IgG subclasses

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10.1016/j.jinf.2021.02.024

MoncuillEtal2021HIVInfectionAndPlacentalMalariaReduceMaternalTransferOfMultipleAntimalarialAntibodiesInMozambicanWomanAccepted author manuscript, 1.18 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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Alonso, S., Vidal, M., Ruiz-Olalla, G., González, R., Jairoce, C., Manaca, M. N., Vázquez-Santiago, M., Balcells, R., Vala, A., Ruperez, M., Cisteró, P., Fuente-Soro, L., Angov, E., Coppel, R. L., Gamain, B., Cavanagh, D., Beeson, J. G., Nhacolo, A., Sevene, E., ... Moncunill, G. (2021). HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women. Journal of Infection, 82(4), 45-57. https://doi.org/10.1016/j.jinf.2021.02.024

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title = "HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women",

abstract = "ObjectivesMaternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses.MethodsIn a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens: Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (EXP1), merozoite surface proteins 1, 2 and 5, and reticulocyte-binding-homologue-4.2 (Rh4.2). We performed univariable and multivariable regression models to assess the association of maternal HIV infection, placental malaria, maternal variables and pregnancy outcomes on cord antibody levels and antibody transplacental transfer.ResultsMaternal antibody levels were the main determinants of cord antibody levels. HIV infection and placental malaria reduced the transfer and cord levels of IgG and IgG1, and this was antigen-dependent. Low birth weight was associated with an increase of IgG2 in cord against EXP1 and Rh4.2.",

keywords = "maternal antibodies, cord blood antibodies, placental transfer, HIV, placental malaria, IgG, IgG subclasses",

author = "Selena Alonso and Marta Vidal and Gemma Ruiz-Olalla and Raquel Gonz{\'a}lez and Chenjerai Jairoce and Manaca, {M. Nelia} and Miquel V{\'a}zquez-Santiago and Reyes Balcells and Anifa Vala and Mar{\'i}a Ruperez and Pau Cister{\'o} and Laura Fuente-Soro and Evelina Angov and Coppel, {Ross L.} and Benoit Gamain and David Cavanagh and Beeson, {James G.} and Arsenio Nhacolo and Esperan{\c c}a Sevene and Aponte, {John J.} and Eus{\'e}bio Macete and Ruth Aguilar and Alfredo Mayor and Clara Men{\'e}ndez and Carlota Doba{\~n}o and Gemma Moncunill",

year = "2021",

month = apr,

day = "1",

doi = "10.1016/j.jinf.2021.02.024",

language = "English",

volume = "82",

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Alonso, S, Vidal, M, Ruiz-Olalla, G, González, R, Jairoce, C, Manaca, MN, Vázquez-Santiago, M, Balcells, R, Vala, A, Ruperez, M, Cisteró, P, Fuente-Soro, L, Angov, E, Coppel, RL, Gamain, B, Cavanagh, D, Beeson, JG, Nhacolo, A, Sevene, E, Aponte, JJ, Macete, E, Aguilar, R, Mayor, A, Menéndez, C, Dobaño, C & Moncunill, G 2021, 'HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women', Journal of Infection, vol. 82, no. 4, pp. 45-57. https://doi.org/10.1016/j.jinf.2021.02.024

TY - JOUR

T1 - HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

AU - Alonso, Selena

AU - Vidal, Marta

AU - Ruiz-Olalla, Gemma

AU - González, Raquel

AU - Jairoce, Chenjerai

AU - Manaca, M. Nelia

AU - Vázquez-Santiago, Miquel

AU - Balcells, Reyes

AU - Vala, Anifa

AU - Ruperez, María

AU - Cisteró, Pau

AU - Fuente-Soro, Laura

AU - Angov, Evelina

AU - Coppel, Ross L.

AU - Gamain, Benoit

AU - Cavanagh, David

AU - Beeson, James G.

AU - Nhacolo, Arsenio

AU - Sevene, Esperança

AU - Aponte, John J.

AU - Macete, Eusébio

AU - Aguilar, Ruth

AU - Mayor, Alfredo

AU - Menéndez, Clara

AU - Dobaño, Carlota

AU - Moncunill, Gemma

PY - 2021/4/1

Y1 - 2021/4/1

N2 - ObjectivesMaternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses.MethodsIn a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens: Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (EXP1), merozoite surface proteins 1, 2 and 5, and reticulocyte-binding-homologue-4.2 (Rh4.2). We performed univariable and multivariable regression models to assess the association of maternal HIV infection, placental malaria, maternal variables and pregnancy outcomes on cord antibody levels and antibody transplacental transfer.ResultsMaternal antibody levels were the main determinants of cord antibody levels. HIV infection and placental malaria reduced the transfer and cord levels of IgG and IgG1, and this was antigen-dependent. Low birth weight was associated with an increase of IgG2 in cord against EXP1 and Rh4.2.

AB - ObjectivesMaternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses.MethodsIn a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens: Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (EXP1), merozoite surface proteins 1, 2 and 5, and reticulocyte-binding-homologue-4.2 (Rh4.2). We performed univariable and multivariable regression models to assess the association of maternal HIV infection, placental malaria, maternal variables and pregnancy outcomes on cord antibody levels and antibody transplacental transfer.ResultsMaternal antibody levels were the main determinants of cord antibody levels. HIV infection and placental malaria reduced the transfer and cord levels of IgG and IgG1, and this was antigen-dependent. Low birth weight was associated with an increase of IgG2 in cord against EXP1 and Rh4.2.

KW - maternal antibodies

KW - cord blood antibodies

KW - placental transfer

KW - HIV

KW - placental malaria

KW - IgG

KW - IgG subclasses

U2 - 10.1016/j.jinf.2021.02.024

DO - 10.1016/j.jinf.2021.02.024

M3 - Article

VL - 82

SP - 45

EP - 57

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 4

ER -

HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

Abstract

Keywords

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