HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS

Elke Braems; Valérie Bercier; Evelien Van Schoor; Kara Heeren; Jimmy Beckers; Laura Fumagalli; Lieselot Dedeene; Matthieu Moisse; Ilse Geudens; Nicole Hersmus; Arpan R. Mehta; Bhuvaneish T. Selvaraj; Siddharthan Chandran; Ritchie Ho; Dietmar R. Thal; Philip Van Damme; Bart Swinnen; Ludo Van Den Bosch

doi:10.1007/s00401-022-02471-y

HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS

Elke Braems, Valérie Bercier, Evelien Van Schoor, Kara Heeren, Jimmy Beckers, Laura Fumagalli, Lieselot Dedeene, Matthieu Moisse, Ilse Geudens, Nicole Hersmus, Arpan R. Mehta, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Ritchie Ho, Dietmar R. Thal, Philip Van Damme, Bart Swinnen, Ludo Van Den Bosch

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Acta Neuropathologica
DOIs	https://doi.org/10.1007/s00401-022-02471-y
Publication status	Published - 27 Jul 2022

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10.1007/s00401-022-02471-y

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Braems, E., Bercier, V., Van Schoor, E., Heeren, K., Beckers, J., Fumagalli, L., Dedeene, L., Moisse, M., Geudens, I., Hersmus, N., Mehta, A. R., Selvaraj, B. T., Chandran, S., Ho, R., Thal, D. R., Van Damme, P., Swinnen, B., & Van Den Bosch, L. (2022). HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS. Acta Neuropathologica. https://doi.org/10.1007/s00401-022-02471-y

@article{eaf22096b8594a8c99601bf2a28465d9,

title = "HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS",

author = "Elke Braems and Val{\'e}rie Bercier and {Van Schoor}, Evelien and Kara Heeren and Jimmy Beckers and Laura Fumagalli and Lieselot Dedeene and Matthieu Moisse and Ilse Geudens and Nicole Hersmus and Mehta, {Arpan R.} and Selvaraj, {Bhuvaneish T.} and Siddharthan Chandran and Ritchie Ho and Thal, {Dietmar R.} and {Van Damme}, Philip and Bart Swinnen and {Van Den Bosch}, Ludo",

note = "Funding Information: We gratefully thank the VIB Nucleomics expertise center for designing and performing RNA-sequencing experiments, A. Isaacs (University College London, UK) for gifting the C9orf72 repeat constructs, and A. Ronisz and S. Ospitalieri (Laboratory for Neuropathology, KU Leuven, Belgium) for the technical help with the post-mortem stainings. This project was supported by the VIB, the University of Leuven (C1 (C14-17-107) and “Opening the Future{\textquoteright} fund), “Fund for Scientific Research Flanders” (FWO-Vlaanderen, G0C1620N), the ALS Association (ALSA), the Thierry Latran Foundation, the “Association Belge contre les Maladies neuro-Musculaires-aide {\`a} la recherch{\'e} ASBL” (ABMM), the Muscular Dystrophy Association (MDA), the ALS Liga Belgi{\"e} (A Cure for ALS), Target ALS and the Robert Packard Center for ALS Research. E.B., E.V.S. and J.B. are funded by a PhD Fellowship of FWO-Vlaanderen (1145621N, 1S46219N, 11A2321N). V.B. is a Post-doctoral Fellow at FWO-Vlaanderen (12Y9120N). P.V.D. holds a senior clinical investigatorship of FWO-Vlaanderen and is supported through the E. von Behring Chair for Neuromuscular Disorders, the KU Leuven ALS fund {\textquoteleft}Een hart voor ALS{\textquoteright} and {\textquoteleft}Laeversfonds voor ALS onderzoek{\textquoteright}. B.T.S. is supported by Anne Rowling-DRI fellowship, B.T.S. and S.C. labs receive funding from UK DRI Ltd, funded by the MRC, Alzheimer's Society and Alzheimer's Research UK. A.R.M. was a Lady Edith Wolfson Clinical Fellow and was thus jointly funded by the Medical Research Council (MRC) and the Motor Neurone Disease Association (MR/R001162/1). He also acknowledges support from the Rowling Scholars scheme, administered by the Anne Rowling Regenerative Neurology Clinic, University of Edinburgh. D.R.T. is funded by FWO-Odysseus grant G0F8516N. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jul,

day = "27",

doi = "10.1007/s00401-022-02471-y",

language = "English",

journal = "Acta Neuropathologica",

issn = "0001-6322",

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T1 - HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS

AU - Braems, Elke

AU - Bercier, Valérie

AU - Van Schoor, Evelien

AU - Heeren, Kara

AU - Beckers, Jimmy

AU - Fumagalli, Laura

AU - Dedeene, Lieselot

AU - Moisse, Matthieu

AU - Geudens, Ilse

AU - Hersmus, Nicole

AU - Mehta, Arpan R.

AU - Selvaraj, Bhuvaneish T.

AU - Chandran, Siddharthan

AU - Ho, Ritchie

AU - Thal, Dietmar R.

AU - Van Damme, Philip

AU - Swinnen, Bart

AU - Van Den Bosch, Ludo

N1 - Funding Information: We gratefully thank the VIB Nucleomics expertise center for designing and performing RNA-sequencing experiments, A. Isaacs (University College London, UK) for gifting the C9orf72 repeat constructs, and A. Ronisz and S. Ospitalieri (Laboratory for Neuropathology, KU Leuven, Belgium) for the technical help with the post-mortem stainings. This project was supported by the VIB, the University of Leuven (C1 (C14-17-107) and “Opening the Future’ fund), “Fund for Scientific Research Flanders” (FWO-Vlaanderen, G0C1620N), the ALS Association (ALSA), the Thierry Latran Foundation, the “Association Belge contre les Maladies neuro-Musculaires-aide à la recherché ASBL” (ABMM), the Muscular Dystrophy Association (MDA), the ALS Liga België (A Cure for ALS), Target ALS and the Robert Packard Center for ALS Research. E.B., E.V.S. and J.B. are funded by a PhD Fellowship of FWO-Vlaanderen (1145621N, 1S46219N, 11A2321N). V.B. is a Post-doctoral Fellow at FWO-Vlaanderen (12Y9120N). P.V.D. holds a senior clinical investigatorship of FWO-Vlaanderen and is supported through the E. von Behring Chair for Neuromuscular Disorders, the KU Leuven ALS fund ‘Een hart voor ALS’ and ‘Laeversfonds voor ALS onderzoek’. B.T.S. is supported by Anne Rowling-DRI fellowship, B.T.S. and S.C. labs receive funding from UK DRI Ltd, funded by the MRC, Alzheimer's Society and Alzheimer's Research UK. A.R.M. was a Lady Edith Wolfson Clinical Fellow and was thus jointly funded by the Medical Research Council (MRC) and the Motor Neurone Disease Association (MR/R001162/1). He also acknowledges support from the Rowling Scholars scheme, administered by the Anne Rowling Regenerative Neurology Clinic, University of Edinburgh. D.R.T. is funded by FWO-Odysseus grant G0F8516N. Publisher Copyright: © 2022, The Author(s).

PY - 2022/7/27

Y1 - 2022/7/27

U2 - 10.1007/s00401-022-02471-y

DO - 10.1007/s00401-022-02471-y

M3 - Article

SN - 0001-6322

JO - Acta Neuropathologica

JF - Acta Neuropathologica

ER -