Homeostasis in the mononuclear phagocyte system

Stephen J. Jenkins, David A. Hume*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The mononuclear phagocyte system (MPS) is a family of functionally related cells including bone marrow precursors, blood monocytes, and tissue macrophages. We review the evidence that macrophages and dendritic cells (DCs) are separate lineages and functional entities, and examine whether the traditional view that monocytes are the immediate precursors of tissue macrophages needs to be refined based upon evidence that macrophages can extensively self-renew and can be seeded from yolk sac/foetal liver progenitors with little input from monocytes thereafter. We review the role of the growth factor colony-stimulating factor (CSF)1, and present a model consistent with the concept of the MPS in which local proliferation and monocyte recruitment are connected to ensure macrophages occupy their well-defined niche in most tissues.

Original languageEnglish
Pages (from-to)358-367
Number of pages10
JournalTrends in Immunology
Issue number8
Publication statusPublished - 1 Jan 2014


  • Colony-stimulating factor 1
  • Dendritic cell
  • Hematopoiesis
  • Macrophage
  • Proliferation


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