Homeostatic shutdown of long-term potentiation in the adult hippocampus

Claudia Roth-Alpermann, Richard G M Morris, Martin Korte, Tobias Bonhoeffer

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Homeostasis is a key concept in biology. It enables ecosystems, organisms, organs, and cells to adjust their operating range to values that ensure optimal performance. Homeostatic regulation of the strength of neuronal connections has been shown to play an important role in the development of the nervous system. Here we investigate whether mature neurons also possess mechanisms to prevent the strengthening of input synapses once the limit of their operating range has been reached. Using electrophysiological recordings in hippocampal slices, we show that such a mechanism exists but comes into play only after a considerable number of synapses have been potentiated. Thus, adult neurons can sustain a substantial amount of synaptic strengthening but, once a certain threshold of potentiation is exceeded, homeostatic regulation ensures that no further strengthening can occur.
Original languageEnglish
Pages (from-to)11039-44
Number of pages6
JournalProceedings of the National Academy of Sciences (PNAS)
Issue number29
Publication statusPublished - 2006


Dive into the research topics of 'Homeostatic shutdown of long-term potentiation in the adult hippocampus'. Together they form a unique fingerprint.

Cite this