Projects per year
Csf1r+/Gr-1+ cells failed to populate the bone marrow during inflammatory conditions. Csf1r+/Gr-1- cell recipients revealed eGFP expression in tissue-resident cells marked with homeostatic and inflammatory markers in equal measure. This modulatory effect however was most apparent following transfer of the least differentiated Csf1r-/Gr-1- precursor. In which recipients revealed only homeostatic replenishment of eGFP+ tissue macrophages and dendritic cells despite competition from host-derived (non eGFP) ly-6C+ “inflammatory” monocytes. These data reveal that homeostatic and inflammatory population of tissues by MPS cells can occur via the same precursor population but by independent differentiation pathways. Competitive re-population of tissues occurred between donor derived mononuclear phagocytes and host derived “inflammatory” monocyte and tissue-resident populations. We observed extensive multi-potent potential in pre-Csf1r (pre eGFP) expressing myeloid precursors using eGFP expression to trace their progeny through to tissue-resident mononuclear phagocytes.
|Publication status||Published - 17 Jan 2013|
|Event||EMBO 2013 - Dr Jekyll and Mr Hyde: The Macrophage in Inflammation and Immunity - Marseilles, France|
Duration: 17 Jan 2013 → 19 Jan 2013
|Conference||EMBO 2013 - Dr Jekyll and Mr Hyde: The Macrophage in Inflammation and Immunity|
|Period||17/01/13 → 19/01/13|
FingerprintDive into the research topics of 'Homeostatic vs inflammatory replenishment of tissue mononuclear phagocytes revealed by fate mapping CSF1R myeloid precursors'. Together they form a unique fingerprint.
- 3 Finished
Collie, D., Beard, P., Bishop, S., Bronsvoort, M., Burt, D., Fitzgerald, R., Freeman, T., Gally, D., Gill, A., Glass, E., Hocking, P., Hope, J., Hume, D., Kaiser, P., Mabbott, N., McLachlan, G., Morrison, L., Stevens, J., Stevens, M. & Watson, M.
1/04/12 → 31/03/17
12/07/10 → 11/06/14
Determining the role of cxcr5-expressing dendritic cells in imune function and tse agent neuroinvasion from the intestine
1/05/09 → 30/09/12
- 1 Participation in workshop, seminar, course
Barry Bradford (Participant)17 Jan 2013 → 19 Jan 2013
Activity: Participating in or organising an event types › Participation in workshop, seminar, course