Host cytokine genotype is related to adverse prognosis and systemic inflammation in gastro-oesophageal cancer

Chris Deans, Matthew Rose-Zerilli, Stephen Wigmore, James Ross, Martin Howell, Alan Jackson, Robert Grimble, Kenneth Fearon

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic inflammation has been linked with reduced survival in cancer, however, the role of the host cytokine genotype versus tumour phenotype in the generation of this response is not clearly established. This study examined the relationship between cytokine polymorphisms (IL-1beta 511, IL-6 174, IL-10 1082, TNFalpha 308 and LTalpha +252) and serum cytokine concentrations, serum CRP concentration and survival duration in patients with gastro-oesophageal malignancy.
Original languageEnglish
Pages (from-to)329-39
Number of pages11
JournalAnnals of Surgical Oncology
Volume14
Issue number2
DOIs
Publication statusPublished - 2007

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