TY - JOUR
T1 - Host cytokine genotype is related to adverse prognosis and systemic inflammation in gastro-oesophageal cancer
AU - Deans, Chris
AU - Rose-Zerilli, Matthew
AU - Wigmore, Stephen
AU - Ross, James
AU - Howell, Martin
AU - Jackson, Alan
AU - Grimble, Robert
AU - Fearon, Kenneth
PY - 2007
Y1 - 2007
N2 - Systemic inflammation has been linked with reduced survival in cancer, however, the role of the host cytokine genotype versus tumour phenotype in the generation of this response is not clearly established. This study examined the relationship between cytokine polymorphisms (IL-1beta 511, IL-6 174, IL-10 1082, TNFalpha 308 and LTalpha +252) and serum cytokine concentrations, serum CRP concentration and survival duration in patients with gastro-oesophageal malignancy.
AB - Systemic inflammation has been linked with reduced survival in cancer, however, the role of the host cytokine genotype versus tumour phenotype in the generation of this response is not clearly established. This study examined the relationship between cytokine polymorphisms (IL-1beta 511, IL-6 174, IL-10 1082, TNFalpha 308 and LTalpha +252) and serum cytokine concentrations, serum CRP concentration and survival duration in patients with gastro-oesophageal malignancy.
U2 - 10.1245/s10434-006-9122-9
DO - 10.1245/s10434-006-9122-9
M3 - Article
C2 - 17103073
SN - 1068-9265
VL - 14
SP - 329
EP - 339
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 2
ER -